Skip to navigation Skip to content

Plant NLR-types receptors in immune-dependent chromatin remodelling

Important information for event attendees and external visitors

coronavirus (COVID-19)In light of the ongoing government restrictions and advice to mitigate risk of COVID-19 transmission, our events have been rescheduled or moved to online delivery.

Our sites remain on a restricted access condition, and only staff who are doing essential site-specific work or tasks are on site. All other colleagues continue to work from home for the time being.

We have excellent and free to use video conference and conference call systems and are happy to make these facilities available to help you engage with us. Meetings are taking place via video conference with participants joining individually from their own locations; check with the relevant member of staff for advice.

As the situation continues to evolve, please check the UK Government and NHS websites for the latest advice and updates. If you have any questions or concerns, please email

23 June 2015, 11.00am, Free
at New Seminar Room, Dundee and streamed live to Macaulay B Suite, Aberdeen
for scientists, students and other interested parties
By Hrz2 (Own work) [CC BY-SA 3.0 (http:/

In this seminar, hosted by Jens Tilsner from our Cell and Molecular Sciences group, Dr Martin Cann (Durham University) will discuss the role of plant NLR (Nucleotide Binding and C-terminal Leucine Rich Repeat) -type receptors in immune-dependent chromatin remodelling.


​Nucleotide Binding and C-terminal Leucine Rich Repeat (NLR) proteins are key immune regulators that enable plant cells to respond to pathogen attack. Several NLRs act in the nucleus, however, conserved nuclear targets that support their role in immunity are unknown. We observe a structural homology between the nucleotide-binding domain of the Rx1 NLR of potato and DNA replication origin-binding proteins. Consistent with this, Rx1 binds, bends, and melts DNA. Facets of this biochemistry are conserved among NLRs from monocot and dicot species indicating a mechanism generic to at least a subset of NLRs. The coat protein of potato virus X triggers Rx1-DNA binding that requires correct subcellular localization and cytoplasmic activation of Rx1. Rx1 further interacts with a core complex of a transcription factor, chromatin remodelling protein, and proteins that recognise histone epigenetic modifications. These data establish DNA distortion as central to Rx1 immune signalling and defines nuclear DNA as the first conserved molecular target of an activated plant NLR.


Dr Martin Cann researches in the general area of biochemistry with a specific interest in the mechanistic basis of signalling modulated by nucleotides. This interest carries across bacterial, animal, and plant systems.

  • BSc Microbiology, Biochemistry, and Physiology (University of Reading)
  • PhD Virology and Molecular Biology (University of Reading)
  • PDRA (Weill Medical College of Cornell University, USA)
  • Howard Hughes Medical Institute Associate (University of Texas Southwestern Medical Centre, USA)
  • Lecturer (Durham University)

Printed from /events/plant-nlr-types-receptors-immune-dependent-chromatin-remodelling on 10/08/20 09:46:54 AM

The James Hutton Research Institute is the result of the merger in April 2011 of MLURI and SCRI. This merger formed a new powerhouse for research into food, land use, and climate change.