Karen McLean
Current research interests
- Targeting of resistance genes linked to the late blight pathogen Phytophthora infestans located on Chromosome IV of Potato.
Past research
- Development and deployment of molecular markers for genotyping and mapping studies in diploid and tetraploid mapping populations.
- Genetic fingerprinting of the Commonwealth Potato Collection using AFLPs.
Bibliography
- Sharma, S.K.; MacKenzie, K.; McLean, K.; Dale, F.; Daniels, S.; Bryan, G.J., (2018) Linkage disequilibrium and evaluation of genome-wide association mapping models in tetraploid potato., G3: Genes, Genomes, Genetics, 8, 3185-3202.
- Trapero-Mozos, A.; Morris, W.L.; Ducreux, L.J.M.; McLean, K.; Stephens, J.; Torrance, L.; Bryan, G.J.; Hancock, R.D.; Taylor, M.A., (2018) Engineering heat tolerance in potato by temperature-dependent expression of a specific allele of HEAT SHOCK COGNATE 70., Plant Biotechnology Journal, 16, 197-207.
- Chen, X.; Lewandowska, D.; Armstrong, M.R.; Baker, K.; Lim, T.Y.; Bayer, M.; Harrower, B.; McLean, K.; Jupe, F.; Witek, K.; Lees, A.K.; Jones, J.D.; Bryan, G.J.; Hein, I., (2018) Identification and rapid mapping of a gene conferring broad-spectrum late blight resistance in the diploid potato species Solanum verrucosum through DNA capture technologies., Theoretical and Applied Genetics, 131, 1287-1297.
- Bryan, G.J.; McLean, K.; Waugh, R.; Spooner, D.M., (2017) Levels of intra-specific AFLP diversity in tuber-bearing potato species with different breeding systems and ploidy levels., Frontiers in Genetics, 8, Article No. 119.
- Destefanis, M.; Nagy, I.; Rigney, B.; Bryan, G.J.; McLean, K.; Hein, I.; Griffin, D.; Milbourne, D., (2015) A disease resistance locus on potato and tomato chromosome 4 exhibits a conserved multipartite structure displaying different rates of evolution in different lineages., BMC Plant Biology, 15, Article No. 255.
- Prashar, A.; Hornyik, C.; Young, V.; McLean, K.; Sharma, S.K.; Dale, M.F.B.; Bryan, G.J., (2014) Construction of a dense SNP map of a highly heterozygous diploid potato population and QTL analysis of tuber shape and eye depth., Theoretical and Applied Genetics, 127, 2159-2171.
- Hackett, C.A.; McLean, K.; Bryan, G.J., (2013) Linkage analysis and QTL mapping using SNP dosage data in a tetraploid potato mapping population., PLoS ONE, 8, Article No. e63939
- Sharma, S.K.; Bolser, D.; de Boer, J.; Sonderkaer, M.; Amoros, W.; Carboni, M.F.; D'Ambrosio, J.M.; de la Cruz, G.; Di Genova, A.; Douches, D.S.; Eguiluz, M.; Guo, X.; Guzman, F.; Hackett, C.A.; Hamilton, J.P.; Li, G.C.; Li, Y.; Lozano, R.; Maass, A.; Marshall, D.; Martinez, D.; McLean, K.; Mejia, N.; Milne, L.; Munive, S.; Nagy, I.; Ponce, O.; Ramirez, M.; Simon, R.; Thomson, S.J.; Torres, Y.; Waugh, R.; Zhang, Z.H.; Huang, S.W.; Visser, R.G.F.; Bachem, C.W.B.; Sagredo, B.; Feingold, S.E.; Orjeda, G.; Veilleux, R.E.; Bonierbale, M.; Jacobs, J.M.E.; Milbourne, D.; Martin, D.M.A.; Bryan, G.J., (2013) Construction of reference chromosome-scale Pseudomolecules for potato: integrating the potato genome with genetic and physical maps., G3-Genomes Genomes Genetics, 3, 2031-2047.
- Schultz, L.; Cogan, N.O.I.; McLean, K.; Dale, M.F.B.; Bryan, G.J.; Forster, J.W.; Slater, A.T., (2012) Evaluation and implementation of a potential diagnostic molecular marker for H1-conferred potato cyst nematode resistance in potato (Solanum tuberosum L.)., Plant Breeding, 131, 315-321.
- Moloney, C.; Griffin, D.; Jones, P.W.; Bryan, G.J.; McLean, K.; Bradshaw, J.E.; Milbourne, D., (2010) Development of diagnostic markers for use in breeding potatoes resistance to Globodera pallida pathotype Pa2/3 using germplasm derived from Solanum tuberosum ssp. andigena CPC 2802., Theoretical and Applied Genetics, 120, 679-689.
- Bradshaw, J.E.; Hackett, C.A.; Lowe, R.; McLean, K.; Stewart, H.E.; Tierney, I.; Vilaro, M.D.R.; Bryan, G.J., (2006) Detection of a quantitative trait locus for both foliage and tuber resistance to late blight [Phytophthora infestans (Mont.) de Bary] on chromosome 4 of a dihaploid potato clone (Solanum tubersoum subsp. tuberosum)., Theoretical and Applied Genetics, 113, 943-951.
- Bradshaw, J.E.; Bryan, G.J.; Lees, A.K.; McLean, K.; Solomon-Blackburn, R.M., (2006) Mapping the R10 and R11 genes for resistance to late blight (Phytophthora infestans) present in the potato (Solanum tuberosum) R-gene differentials of Black., Theoretical and Applied Genetics, 112, 744-751.
- Spooner, D.M.; McLean, K.; Ramsay, G.; Waugh, R.; Bryan, G.J., (2005) A single domestication for potato based on multilocus amplified fragment length polymorphism genotyping., Proceedings of the National Academy of Sciences of the United States of America (PNAS), 102, 14694-14699.
- Bryan, G.J.; McLean, K.; Waugh, R.; Spooner, D.M.; Ramsay, G., (2005) A single domestication for cultivated potato., Annual Report of the Scottish Crop Research Institute for 2004/2005, pp16-17.
- Bradshaw, J.E.; Bryan, G.J.; Hackett, C.A.; McLean, K.; Pande, B.; Stewart, H.E.; Waugh, R., (2004) Dissection and analysis of quantitative disease resistance in tetraploid potato., Euphytica, 137, 13-18.
- Bradshaw, J.E.; Pande, B.; Bryan, G.J.; Hackett, C.A.; McLean, K.; Stewart, H.E.; Waugh, R., (2004) Interval mapping of quantitative trait loci for resistance to late blight [Phytophthora infestans (Mont.) de Bary], height and maturity in a tetraploid population of potato (Solanum tuberosum subsp. tuberosum)., Genetics, 168, 983-995.
- Bryan, G.J.; McLean, K.; Pande, B.; Purvis, A.; Hackett, C.A.; Bradshaw, J.E.; Waugh, R., (2004) Genetical dissection of H3-mediated polygenic PCN resistance in a heterozygous autotetraploid potato population., Molecular Breeding, 14, 105-116.
- Bryan, G.J.; McLean, K.; Bradshaw, J.E.; de Jong, W.S.; Phillips, M.S.; Castelli, L.; Waugh, R., (2002) Mapping QTLs for resistance to the cyst nematode Globodera pallida derived from the wild potato species Solanum vernei., Theoretical and Applied Genetics, 105, 68-77.
- Bryan, G.J.; Milbourne, D.; Isidore, E.; McNicoll, J.; Tierney, I.; Purvis, A.; Williamson, S.; Ramsay, L.; McLean, K.; Waugh, R., (2002) Application of a potato UHD genetic linkage map for BAC landing and contig initiation in a region of linkage group V., Annual Report of the Scottish Crop Research Institute for 2001/2002, pp143-146.
- Waugh, R.; McLean, K.; Flavell, A.J.; Pearce, S.R.; Kumar, A.; Thomas, W.T.B.; Powell, W., (1997) Genetic distribution of Bare-1-like retrotransposable elements in the barley genome revealed by sequence-specific amplification polymorphisms (S-SAP)., Molecular and General Genetics, 253, 687-694.
- Kumar, A.; Pearce, S.R.; McLean, K.; Harrison, G.; Heslop-Harrison, J.S.; Waugh, R.; Flavell, A.J., (1997) The Ty1-copia group of retrotransposons in plants: genomic organisation, evolution, and use as molecular markers., Genetica, 100, 205-217.
- Sharma, S.K.; MacKenzie, K.; McLean, K.; Dale, F.; Daniels, S.; Bryan, G.J., (2018) Linkage disequilibrium and evaluation of genome-wide association mapping models in tetraploid potato., G3: Genes, Genomes, Genetics, 8, 3185-3202.
- Trapero-Mozos, A.; Morris, W.L.; Ducreux, L.J.M.; McLean, K.; Stephens, J.; Torrance, L.; Bryan, G.J.; Hancock, R.D.; Taylor, M.A., (2018) Engineering heat tolerance in potato by temperature-dependent expression of a specific allele of HEAT SHOCK COGNATE 70., Plant Biotechnology Journal, 16, 197-207.
- Chen, X.; Lewandowska, D.; Armstrong, M.R.; Baker, K.; Lim, T.Y.; Bayer, M.; Harrower, B.; McLean, K.; Jupe, F.; Witek, K.; Lees, A.K.; Jones, J.D.; Bryan, G.J.; Hein, I., (2018) Identification and rapid mapping of a gene conferring broad-spectrum late blight resistance in the diploid potato species Solanum verrucosum through DNA capture technologies., Theoretical and Applied Genetics, 131, 1287-1297.
- Bryan, G.J.; McLean, K.; Waugh, R.; Spooner, D.M., (2017) Levels of intra-specific AFLP diversity in tuber-bearing potato species with different breeding systems and ploidy levels., Frontiers in Genetics, 8, Article No. 119.
- Destefanis, M.; Nagy, I.; Rigney, B.; Bryan, G.J.; McLean, K.; Hein, I.; Griffin, D.; Milbourne, D., (2015) A disease resistance locus on potato and tomato chromosome 4 exhibits a conserved multipartite structure displaying different rates of evolution in different lineages., BMC Plant Biology, 15, Article No. 255.
- Prashar, A.; Hornyik, C.; Young, V.; McLean, K.; Sharma, S.K.; Dale, M.F.B.; Bryan, G.J., (2014) Construction of a dense SNP map of a highly heterozygous diploid potato population and QTL analysis of tuber shape and eye depth., Theoretical and Applied Genetics, 127, 2159-2171.
- Hackett, C.A.; McLean, K.; Bryan, G.J., (2013) Linkage analysis and QTL mapping using SNP dosage data in a tetraploid potato mapping population., PLoS ONE, 8, Article No. e63939
- Sharma, S.K.; Bolser, D.; de Boer, J.; Sonderkaer, M.; Amoros, W.; Carboni, M.F.; D'Ambrosio, J.M.; de la Cruz, G.; Di Genova, A.; Douches, D.S.; Eguiluz, M.; Guo, X.; Guzman, F.; Hackett, C.A.; Hamilton, J.P.; Li, G.C.; Li, Y.; Lozano, R.; Maass, A.; Marshall, D.; Martinez, D.; McLean, K.; Mejia, N.; Milne, L.; Munive, S.; Nagy, I.; Ponce, O.; Ramirez, M.; Simon, R.; Thomson, S.J.; Torres, Y.; Waugh, R.; Zhang, Z.H.; Huang, S.W.; Visser, R.G.F.; Bachem, C.W.B.; Sagredo, B.; Feingold, S.E.; Orjeda, G.; Veilleux, R.E.; Bonierbale, M.; Jacobs, J.M.E.; Milbourne, D.; Martin, D.M.A.; Bryan, G.J., (2013) Construction of reference chromosome-scale Pseudomolecules for potato: integrating the potato genome with genetic and physical maps., G3-Genomes Genomes Genetics, 3, 2031-2047.
- Schultz, L.; Cogan, N.O.I.; McLean, K.; Dale, M.F.B.; Bryan, G.J.; Forster, J.W.; Slater, A.T., (2012) Evaluation and implementation of a potential diagnostic molecular marker for H1-conferred potato cyst nematode resistance in potato (Solanum tuberosum L.)., Plant Breeding, 131, 315-321.
- Moloney, C.; Griffin, D.; Jones, P.W.; Bryan, G.J.; McLean, K.; Bradshaw, J.E.; Milbourne, D., (2010) Development of diagnostic markers for use in breeding potatoes resistance to Globodera pallida pathotype Pa2/3 using germplasm derived from Solanum tuberosum ssp. andigena CPC 2802., Theoretical and Applied Genetics, 120, 679-689.
- Bradshaw, J.E.; Hackett, C.A.; Lowe, R.; McLean, K.; Stewart, H.E.; Tierney, I.; Vilaro, M.D.R.; Bryan, G.J., (2006) Detection of a quantitative trait locus for both foliage and tuber resistance to late blight [Phytophthora infestans (Mont.) de Bary] on chromosome 4 of a dihaploid potato clone (Solanum tubersoum subsp. tuberosum)., Theoretical and Applied Genetics, 113, 943-951.
- Bradshaw, J.E.; Bryan, G.J.; Lees, A.K.; McLean, K.; Solomon-Blackburn, R.M., (2006) Mapping the R10 and R11 genes for resistance to late blight (Phytophthora infestans) present in the potato (Solanum tuberosum) R-gene differentials of Black., Theoretical and Applied Genetics, 112, 744-751.
- Spooner, D.M.; McLean, K.; Ramsay, G.; Waugh, R.; Bryan, G.J., (2005) A single domestication for potato based on multilocus amplified fragment length polymorphism genotyping., Proceedings of the National Academy of Sciences of the United States of America (PNAS), 102, 14694-14699.
- Bradshaw, J.E.; Bryan, G.J.; Hackett, C.A.; McLean, K.; Pande, B.; Stewart, H.E.; Waugh, R., (2004) Dissection and analysis of quantitative disease resistance in tetraploid potato., Euphytica, 137, 13-18.
- Bradshaw, J.E.; Pande, B.; Bryan, G.J.; Hackett, C.A.; McLean, K.; Stewart, H.E.; Waugh, R., (2004) Interval mapping of quantitative trait loci for resistance to late blight [Phytophthora infestans (Mont.) de Bary], height and maturity in a tetraploid population of potato (Solanum tuberosum subsp. tuberosum)., Genetics, 168, 983-995.
- Bryan, G.J.; McLean, K.; Pande, B.; Purvis, A.; Hackett, C.A.; Bradshaw, J.E.; Waugh, R., (2004) Genetical dissection of H3-mediated polygenic PCN resistance in a heterozygous autotetraploid potato population., Molecular Breeding, 14, 105-116.
- Bryan, G.J.; McLean, K.; Bradshaw, J.E.; de Jong, W.S.; Phillips, M.S.; Castelli, L.; Waugh, R., (2002) Mapping QTLs for resistance to the cyst nematode Globodera pallida derived from the wild potato species Solanum vernei., Theoretical and Applied Genetics, 105, 68-77.
- Waugh, R.; McLean, K.; Flavell, A.J.; Pearce, S.R.; Kumar, A.; Thomas, W.T.B.; Powell, W., (1997) Genetic distribution of Bare-1-like retrotransposable elements in the barley genome revealed by sequence-specific amplification polymorphisms (S-SAP)., Molecular and General Genetics, 253, 687-694.
- Kumar, A.; Pearce, S.R.; McLean, K.; Harrison, G.; Heslop-Harrison, J.S.; Waugh, R.; Flavell, A.J., (1997) The Ty1-copia group of retrotransposons in plants: genomic organisation, evolution, and use as molecular markers., Genetica, 100, 205-217.
- Bryan, G.J.; McLean, K.; Waugh, R.; Spooner, D.M.; Ramsay, G., (2005) A single domestication for cultivated potato., Annual Report of the Scottish Crop Research Institute for 2004/2005, pp16-17.
- Bryan, G.J.; Milbourne, D.; Isidore, E.; McNicoll, J.; Tierney, I.; Purvis, A.; Williamson, S.; Ramsay, L.; McLean, K.; Waugh, R., (2002) Application of a potato UHD genetic linkage map for BAC landing and contig initiation in a region of linkage group V., Annual Report of the Scottish Crop Research Institute for 2001/2002, pp143-146.
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