- Logie, L.; Bacon, S.; Middleton, P.; Harthill, J.; Coats, J.; Stewart, D.; Sakamoto, K.; McDougall, G.; Rena, G., (2013) How does glucophage (metaformin) work? Investigation of the cellular action of chemical analogues., Diabetes UK Professional Conference, Manchester Central, Manchester, 13-15 March 2013.
- Cameron, A.; Logie, L.; Patel, K.; Bacon, S.; Forteath, C.; Harthill, J.; Roberts, A.; Sutherland, C.D.; Stewart, D.; Viollet, B.; Sakamoto, K.; McDougall, G.; Foretz, M.; Rena, G., (In press) Investigation of salicylate hepatic responses in comparison with chemical analogues of the drug., BBA - Molecular Basis of Disease.
- Ewert, F.; Rotter, R.P.; Bindi, M.; Webber, H.; Trnka, M.; Kersebaum, K.C.; Olesen, J.E.; van Ittersum, M.K.; Janssen, S.; Rivington, M.; Semenov, M.A.; Wallach, D.; Porter, J.R.; Stewart, D.; Verhagen, J.; Gaiser, T.; Palosuo, T.; Tao, F.; Nendel, C.; Roggero, P.P.; Bartosova, L.; Asseng, S., (2015) Crop modelling for integrated assessment of risk to food production from climate change., Environmental Modelling and Software, 72, 287-303.
- Foito, A.; Hackett, C.A.; Byrne, S.L.; Stewart, D.; Barth, S., (2015) Quantitative trait loci analysis to study the genetic regulation of non-polar metabolites in perennial ryegrass., Metabolomics, 11, 412-424.
- Macedo, D.; Tavares, L.; McDougall, G.J.; Miranda, H.V.; Stewart, D.; Ferreira, R.B.; Tenreiro, S.; Outeiro, T.F.; Santos, C.N., (2015) (Poly)phenols protect from alpha-synuclein toxicity by reducing oxidative stress and promoting autophagy., Human Molecular Genetics, 24, 1717-1732.
- Multari, S.; Stewart, D.; Russell, W.R., (2015) Potential of Fava Bean as future protein supply to partially replace meat intake in the human diet., Comprehensive Reviews in Food Science and Safety, 14, 511-522.
- Shepherd, L.V.T.; Hackett, C.A,.; Alexander, C.A.; McNicol, J.W.; Sungurtas, J.A.; Stewart, D.; McCue, K.; Belknap, W.R.; Davies, H.V., (2015) Modifying glycoalkaloid content in transgenic potato - Metabolome impacts., Food Chemistry, 187, 437-443.
- Stavang, J.A.; Freitag, S.; Foito, A.; Verrall, S.; Heide, O.M.; Stewart, D.; Sonsteby, A., (2015) Raspberry fruit quality changes during ripening and storage as assessed by colour, sensory evaluation and chemical analyses., Scientia Horticulturae, 195, 216-225.
- Vagiri, M.; Conner, S.; Stewart, D.; Andersson, S.C.; Verrall, S.; Johansson, E.; Rumpunen, K., (2015) Phenolic compounds in blackcurrant (Ribes nigrum L.) leaves relative to leaf position and harvest date., Food Chemistry, 172, 135-142.
- Brown, E.M.; Latimer, C.; Allsopp, P.; Ternan, N.G.; McMullan, G.; McDougall, G.J.; Stewart, D.; Crozier, A.; Rowland, I.; Gill, C.I.R., (2014) In vitro and in vivo models of colorectal cancer: antigenotoxic activity of berries., Journal of Agricultural and Food Chemistry, 62, 3852-3866.
- Brown, E.M.; Nitecki, S.; Pereira-Caro, G.; McDougall, G.J.; Stewart, D.; Rowland, I.; Crozier, A.; Gill, C.I.R., (2014) Comparison of in vivo and in vitro digestion on polyphenol composition in lingonberries: potential impact on colonic health., Biofactors, 40, 611-623.
- Cognat, C.; Shepherd, T.; Verrall, S.R.; Stewart, D., (2014) Relationship between volative profile and sensory development of an oat based biscuit., Food Chemistry, 160, 72-81.
- Diamanti, J.; Mazzoni, L.; Balducci, F.; Capelletti, T.; Capocasa, F.; Battino, M.; Dobson, G.; Stewart, D.; Mezzetti, B., (2014) Use of wild genotypes in breeding program increases strawberry fruit sensorial and nutritional quality., Journal of Agricultural and Food Chemistry, 62, 3944-3953.
- Mazur, S.P.; Sonsteby, A.; Nes, A.; Wold, A.B.; Foito, A.; Freitag, S.; Verrall, S.; Stewart, D.; Heide, O.M., (2014) Effects of Post-Flowering Environmental Variation along an Altitudinal Gradient on Chemical Composition of 'Glen Ample' Red Raspberry (Rubus idaeus L.)., European Journal of Horticultural Science, 79, 267-277.
- Mazur, S.P.; Sonsteby, A.; Wold, A.B.; Foito, A.; Freitag, S.; Verrall, S.; Conner, S.; Stewart, D.; Heide, O.M., (2014) Post-flowering photoperiod has marked effects on fruit chemical composition in red raspberry (Rubus idaeus)., Annals of Applied Biology, 165, 454-465.
- McDougall, G.J.; Conner, S.; Pereira-Caro, G.; Gonzalez-Barrio, R.; Brown, E.M.; Verrall, S.; Stewart, D.; Moffet, T.; Ibars, M.; Lawther, R.; O'Connor, G.; Rowland, I.; Crozier, A.; Gill, C.I.R., (2014) Tracking (poly)phenol components from raspberries in ileal fluid., Journal of Agricultural and Food Chemistry, 62, 7631-7641.
- Pimpao, R.C.; Dew, T.; Figueira, M.E.; McDougall, G.J.; Stewart, D.; Ferreira, R.B.; Santos, C.N.; Williamson, G., (2014) Urinary metabolite profiling identifies novel colonic metabolites and conjugates of phenolics in healthy volunteers., Molecular Nutrition and Food Research, 58, 1414-1425.
- Shepherd, L.V.T.; Hackett, C.A.; Alexander, C.J.; Sungurtas, J.A.; Pont, S.D.A.; Stewart, D.; McNicol, J.W.; Wilcockson, S.J.; Leifert, C.; Davies, H.V., (2014) Effect of agricultural production systems on the potato metabolome., Metabolomics, 10, 212-224.
- Dincheva, I.; Badjakov, I.; Kondakova, V.; Dobson, P.; McDougall, G.; Stewart, D., (2013) Identification of the phenolic components in Bulgarian raspberry cultivars by LC-ESI-MSn., International Journal of Agricultural Science Research, 3, 127-137.
- Foito, A.; Byrne S.L.; Hackett, C.A.; Hancock, R.D.; Stewart, D.; Barth, S., (2013) Short-term response in leaf metabolism of perennial ryegrass (Lolium perenne) to alterations in nitrogen supply., Metabolomics, 9, 145-156.
- Josuttis, M.; Verrall, S.; Stewart, D.; Kruger, E.; McDougall, G.J., (2013) Genetic and environmental effects on tannin composition in strawberry (Fragaria x ananassa) cultivars grown in different European locations., Journal of Agricultural and Food Chemistry, 61, 790-800.
Current research interests
Metabolomics - the desire to delve ever deeper and wider into plant composition has been driven by the necessity to obtains a better understanding of the factors which govern and drive plant metabolism and therefore ultimately define the end quality, health and nutrition traits. Metabolomics, the simultaneous and untargeted analysis of multiple metabolites at a defined timeframe, is the focus of an intense research effort covering several biological issues. These include metabolites changes in relation to plant-food organolepsis (see below), the potato tuber life cycle, the influence of genetics versus environment (potato and soft fruit), biodiversity etc. The technologies developed via these approaches have attracted great interest and have led to significant external funding.
- Development of unified data models and data pre-processing strategies and the generation of meaningful, standardised statistical analyses of metabolome variability in crop plants (Food Standards Agency).
- Transcriptome, proteome and metabolome analysis to detect unintended effects in genetically modified potato (Food Standards Agency).
- Quantitative risk assessment strategies for novel foods (NOFORISK, EU).
- Promoting food safety through a new integrated risk analysis approach to foods (SAFEFOOD, EU).
- Assessment of plant germplasm for bioactive molecules (Scottish Government).
Linking plant composition to health benefits - it is clear that plant-derived foods are required and generally beneficial to human health. It is only now that real details are being elucidated with regard to the basis and mechanisms by which plants exert these benefits. As part of several core and external collaborations we are seeking to determine which phytochemicals in soft fruit, potatoes and other main and niche crops are the key determinants of health benefits. These studies have benefited by several links to key collaborative groups such as RRI, NICHE and the new Centre for Health Inducing Plants (CHIP), a virtual centre comprising The James Hutton Institute and The University of Dundee Medical School
Organoleptic basis of plant-derived foods - the organoleptic qualities, flavour, aroma, texture and visual appearance are the driving factors in food consumption. However each of these parameters are multi-component and interrelated. Although the subject of intense study the basis of flavour aroma and texture in potato remains unclear. However through collaborations with the Genetics programme, who have unique germplasm segregating in organoleptic parameters, and by applying rigorous and concerted chemical, biochemical, physical and molecular biological approaches we aim to take this area forward. Analogous studies are also being done with soft fruit.
- April 2011-present: Enhancing Crop Productivity and Utilisation Research Theme Leader, The James Hutton Institute.
- 2005-April 2011: Head of Plant Products and Food Quality programme, SCRI.
- 2000-05 - Principal Investigator (Band 4), Quality Health and Nutrition programme, SCRI.
- 1997-2000 - Senior Scientific Officer (Band 5), Unit of Industrial Crops, SCRI.
- 1989-97 - Higher Scientific Officer (Band 6), Unit of Industrial Crops, SCRI.
- 1987-89 - Higher Scientific Officer, SCRI (FF Project - Production of monoclonal antibodies to surface (glyco)-proteins on potato cyst nematodes).
- 1985-87 - Research Assistant, Fisons Pharmaceuticals, Loughborough, UK.
- McCue, K.F., Allen, P.V., Shepherd, L.V.T, Blake, A., Whitworth, J., Maccreea, M.M., Rockhold, D.R., Stewart, D., Davies, H.V., Belknap, W.R. 2006. The Primary In Vivo Steroidal Alkaloid Glucosyltransferase From Potato. Phytochemistry 67(15), 1590-7.
- Nuopponen, M., Birch, G.M., Sykes, R., Lee, S. and Stewart, D. 2006. Estimation of wood density and chemical composition by means of Diffuse Reflectance Infrared Fourier Transform (DRIFT) spectroscopy. Journal of Agricultural and Food Chemistry 54(1), 34-40.
- Nuopponen, M., Wikberg, H.I., Birch, G.M., Jããskelãinen, A.-S., Maunu, S.L., Vuorinen, T. and Stewart, D. 2006. Characterization of 25 tropical hardwoods with FT-IR, UV resonance Raman (UVRR) and 13C CPMAS NMR spectroscopy. Journal of Applied Polymer Science 102(1), 810-819.
- McDougall, G.J. and Stewart, D. 2006. The inhibitory effects of berry polyphenols on digestive enzymes. Biofactors 23(4), 189 – 195.
- McDougall, G.J., Shpiro, F., Dobson, P., Smith, P., Blake, A. and Stewart, D. 2005. Different polyphenolic components of soft fruits inhibit α-Amylase and α-Glucosidase. Journal of Agricultural and Food Chemistry 53, 2760-2766.
- McDougall, G.J., Gordon, S.L., Brennan, R.M. and Stewart, D. 2005. Anthocyanin-flavanol adducts from blackcurrant (Ribes nigrum L.). Journal of Agricultural and Food Chemistry 53(20), 7878-85.
- McDougall, G.J., Fyffe, S., Dobson, P. and Stewart, D. 2005. Anthocyanins from red wine – their stability under simulated gastrointestinal digestion. Phytochemistry 66(21), 2540-8.
- McDougall, G.J., Dobson, P., Smith, P., Blake, A. and Stewart, D. 2005. Assessing potential bioavailability of raspberry anthocyanins in an in vitro digestion system. Journal of Agricultural and Food Chemistry 53, 5896-5904.
- Mylnikov, S.V., Kokko, H., Kärenlampi, S., Oparina, T.I., Davies, H.V. and Stewart, D. 2005. Rubus fruit juices affect lipid peroxidation in Drosophila melanogaster model in vivo. Journal of Agricultural and Food Chemistry 53(20), 7728-33.
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