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John Jones

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Recent publications

Staff picture: John Jones
Cell and Molecular Sciences
john.jones@hutton.ac.uk
+44 (0)844 928 5428 (*)

The James Hutton Institute
Invergowrie
Dundee DD2 5DA
Scotland UK

Current research interests 

  • Functional analysis of effectors of plant parasitic nematodes.
  • Genomics of the potato cyst nematode Globodera pallida
  • Horizontal gene transfer in plant parasitic nematodes.

John has a joint appointment at the University of St Andrews

John is part of the Dundee Effector Consortium.

Past research 

  • Work in our group is focused on identification and characterisation of secreted effector proteins of plant parasitic nematodes, with a particular focus on effectors that suppress host defences. 
  • Our work uses genomics tools to identify and characterise effectors.  We have been involved in projects sequencing genomes and transcriptomes of a range of plant-parasitic nematodes.
  • One unexpected finding that has emerged from this work is that genes important in the parasitic process seem to have been acquired by horizontal gene transfer, from bacteria or fungi, in all groups of plant parasitic nematodes studied to date.
  • Current work is aimed at functional characterisation of proteins we suspect are important in generating a susceptible response or suppressing host defences in plants.

Bibliography 

  • Eves-van den Akker, S., Laetsch, D.R., Thorpe, P., Lilley, C.J., Danchin. E.G.J., Da Rocha. M., Rancurel, C., Holroyd, N.E, Cotton, J.A., Szitenberg, A., Grenier, E., Montarry, J., Mimee, B., Duceppe, M-O., Boyes, I., Marvin, J.M.C., Jones, L.M., Yusup, H.B, Lafond-Lapalme, J. Esquibet, M., Sabeh, M., Rott, M., Overmars, H., Finkers-Tomczak, A., Smant, G., Koutsovoulos, G., Blok, V.C., Mantelin, S., Cock, P.J.A., Phillips, W., Henrissat, B., Urwin, P.E, Blaxter, M. & Jones, J.T. (2016).  The genome of the yellow potato cyst nematode, Globodera rostochiensis, reveals insights into the bases of parasitism and virulence.  Genome Biology – in press.

  • Danchin, E.G.J, Guzeeva, E., Mantelin, S., Berepiki, A. & Jones, J.T. (2016).  Horizontal gene transfer from bacteria has enabled the plant-parasitic nematode Globodera pallida to feed on host-derived sucrose. Molecular Biology and Evolution – in press.

  • Thorpe, P., Mantelin, S., Cock, P.J.A., Blok, V.C., Coke, M.C., Cotton, J.A., Eves van den Akker, S., Guzeeva, E., Lilley, C.J., Reid, A.J., Wright, K.M., Urwin, P.E & Jones, J.T. (2014).  Characterisation of the full effector complement of the potato cyst nematode Globodera pallida.  BMC Genomics 15, 923.

  • Eves-van den Akker, S., Lilley, C.J., Jones, J.T. & Urwin, P.E. (2014).  Identification and characterisation of a hyper variable apoplastic effector gene family of G. pallida  PLoS Pathogens 10(9): e1004391.

  • Eves-van den Akker, S., Lilley, C.J., Danchin, E.G.J., Rancurel, C., Cock, P.J.A., Urwin, P.E. & Jones, J.T. (2014).  The Nacobbus aberrans transcriptome reveals insights into the evolution of sedentary endoparasitism in plant-parasitic nematodesGenome Biology & Evolution 6, 2181-2194.

  • Cotton, J.A., Lilley, C.J., Jones, L.M., Kikuchi, T., Reid, A.J., Thorpe, P., Tsai, I.J., Beasley, H., Blok, V.C, Cock, P.J.A., Eves-van den Akker, S., Holroyd, N., Hunt, M., Mantelin, S., Naghra, H. Pain, A., Palomares-Rius, JE., Zarowiecki, M., Berriman, M., Jones, J.T. & Urwin, P.E. (2014).  The genome and life-stage specific transcriptomes of Globodera pallida elucidate key aspects of plant parasitism by a cyst nematode.  Genome Biology 15 R43.
  • Kikuchi, T., Cotton, J.A., Dalzell, J.J., Hasegawa, K, Kanzaki, N. McVeigh, P., Takanashi, T., Tsai, I.J., Assefa S.A., Cock, P.J.A., Otto, T.D., Hunt, M., Reid, A.J., Sanchez-Flores, A., Tsuchihara, K., Yokoi, T., Larsson, M.C., Miwa, J., Maule, A.G., Sahashi, N., Jones, J.T. and Berriman, M. (2011).  Genomic insights into the origin of parasitism in the emerging plant pathogen Bursaphelenchus xylophilus. PLoS Pathogens 7, e1002219
  • Rosso, M.N., Jones, J.T. and Abad, P. 2009.  RNAi and functinoal genomics in plant parasitic nematodes: tools and discoveries in the post-genomic era.  Annual Review of Phytopathology 47, 207-232.
  • Abad, P. et al., (~50 authors including Jones, J.T.).  2008. Genome sequence of the metazoan plant-parasitic nematode Meloidogyne incognitaNature Biotechnology 26, 909-915.
  • Kikuchi, T., Shibuya, H., Aikawa, T. and Jones, J.T. 2006. Cloning and Characterization of Pectate Lyases Secreted by the Pine Wood Nematode Bursaphelenchus xylophilus. Molecular Plant-Microbe Interactions 19, 280-287. 
  • Chen, Q. Rehman, S., Smant, G. and Jones J.T. 2005. Functional analysis of pathogenicity proteins of the potato cyst nematode Globodera rostochiensis using RNAi. Molecular Plant-Microbe Interactions 18, 621-625. 
  • Qin, L., Kudla, U., Roze, E., Goverse, A., Popeijus, H., Nieuwland, J., Overmars, H., Jones, J. T., Schots, A., Smant, G., Bakker, J., Helder, J. 2003. Identification of a functional expansin, a non-enzymatic, cell wall-loosening agent, from the plant parasitic nematode Globodera rostochiensis. Nature 427, 30.
  • Jones, J.T., Furlanetto, C., Bakker, E., Banks, B., Blok, V.C., Chen, Q. and Prior, A. 2003. Characterisation of a chorismate mutase from the potato cyst nematode Globodera pallida. Molecular Plant Pathology 4, 43-50.
  • Popeijus, H., Overmars, H., Jones, J.T., Blok, V.C., Goverse, A., Helder, J., Bakker, J., Schots, A. and Smant, G. 2000. Non-symbiotic degradation of plant cell walls by animals. Nature 406, 36-37.

  • Email: info@hutton.ac.uk
  • Phone: +44 (0)844 928 5428
  • Craigiebuckler Aberdeen AB15 8QH Scotland
  • Invergowrie Dundee DD2 5DA Scotland
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The James Hutton Research Institute is the result of the merger in April 2011 of MLURI and SCRI. This merger formed a new powerhouse for research into food, land use, and climate change.