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John Jones

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Recent publications

Staff picture: John Jones
Cell and Molecular Sciences
john.jones@hutton.ac.uk
+44 (0)844 928 5428 (*)

The James Hutton Institute
Invergowrie
Dundee DD2 5DA
Scotland UK

Current research interests 

  • Functional analysis of effectors of plant parasitic nematodes.
  • Genomics of the potato cyst nematode Globodera pallida
  • Horizontal gene transfer in plant parasitic nematodes.

John was chair of COST Action 872 - "Exploiting genomics to understand plant-nematode interactions".

John is part of the Dundee Effector Consortium.

Past research 

  • Work in our group is focused on identification and characterisation of secreted effector proteins of plant parasitic nematodes, with a particular focus on effectors that suppress host defences. 
  • Our work uses genomics tools to identify and characterise effectors.  We are partners in a project that is sequencing the genome of G. pallida.  We have previously undertaken large scale expressed sequence tag analysis of G. pallida (Jones et al., 2009 - below) and are currently using microarrays and RNAseq to examine changes in gene expression throughout the G. pallida life cycle.
  • One unexpected finding that has emerged from this work is that genes important in the parasitic process seem to have been acquired by horizontal gene transfer, from bacteria or fungi, in all groups of plant parasitic nematodes studied to date.
  • Current work is aimed at functional characterisation of proteins we suspect are important in generating a susceptible response or suppressing host defences in plants.

Bibliography 

  • Jones, J.T., Gheysen, G. and Fenoll, C (Eds) 2011. Genomics and molecular genetics of plant-nematode interactions. Springer Academic Publishers.
  • Haegeman, A., Jones, J.T. and Danchin, E. 2011. Horizontal gene transfer in nematodes: a catalyst for plant parasitism? Molecular Plant-Microbe Interactions (in press).
  • Kikuchi, T., Cotton, J.A., Dalzell, J.J., Hasegawa, K, Kanzaki, N. McVeigh, P., Takanashi, T., Tsai, I.J., Assefa S.A., Cock, P.J.A., Otto, T.D., Hunt, M., Reid, A.J., Sanchez-Flores, A., Tsuchihara, K., Yokoi, T., Larsson, M.C., Miwa, J., Maule, A.G., Sahashi, N., Jones, J.T. and Berriman, M. 2011). Genomic insights into the origin of parasitism in the emerging plant pathogen Bursaphelenchus xylophilus. PLoS Pathogens (in press).
  • Karim, N., Jones, J.T., Okada, H. and Kikuchi, T. 2009. Analysis of expressed sequence tags and identification of genes encoding cell-wall-degrading enzymes from the fungivorous nematode Aphelenchus avenae. BMC Genomics 10, 525.
     
  • Jones, J.T., Kumar, A., Pylypenko, L.A., Thirugnansambandam, A., Castelli, L., Chapman, S., Cock, P.J., Grenier, E., Lilley, C.J., Phillips, M.S. and Blok, V.C. 2009.  Identification and functional characterisation of effectors in Expressed Sequence Tags from various life stages of the potato cyst nematode Globodera pallida. Molecular Plant Pathology 10, 815-828.
  • Rosso, M.N., Jones, J.T. and Abad, P. 2009.  RNAi and functinoal genomics in plant parasitic nematodes: tools and discoveries in the post-genomic era.  Annual Review of Phytopathology 47, 207-232.
  • Abad, P. et al., (~50 authors including Jones, J.T.).  2008. Genome sequence of the metazoan plant-parasitic nematode Meloidogyne incognitaNature Biotechnology 26, 909-915.
  • Kikuchi, T., Aikawa, T., Kosaka, H., Pritchard, L., Ogura, N. and Jones, J.T. 2007. EST analysis of the pine wood nematode Bursaphelenchus xylophilus and B. mucronatusMolecular and Biochemical Parasitology 155, 9-17.
  • Kikuchi, T., Shibuya, H., Aikawa, T. and Jones, J.T. 2006. Cloning and Characterization of Pectate Lyases Secreted by the Pine Wood Nematode Bursaphelenchus xylophilus. Molecular Plant-Microbe Interactions 19, 280-287. 
  • Chen, Q. Rehman, S., Smant, G. and Jones J.T. 2005. Functional analysis of pathogenicity proteins of the potato cyst nematode Globodera rostochiensis using RNAi. Molecular Plant-Microbe Interactions 18, 621-625. 
  • Qin, L., Kudla, U., Roze, E., Goverse, A., Popeijus, H., Nieuwland, J., Overmars, H., Jones, J. T., Schots, A., Smant, G., Bakker, J., Helder, J. 2003. Identification of a functional expansin, a non-enzymatic, cell wall-loosening agent, from the plant parasitic nematode Globodera rostochiensis. Nature 427, 30.
  • Jones, J.T., Furlanetto, C., Bakker, E., Banks, B., Blok, V.C., Chen, Q. and Prior, A. 2003. Characterisation of a chorismate mutase from the potato cyst nematode Globodera pallida. Molecular Plant Pathology 4, 43-50.
  • Popeijus, H., Overmars, H., Jones, J.T., Blok, V.C., Goverse, A., Helder, J., Bakker, J., Schots, A. and Smant, G. 2000. Non-symbiotic degradation of plant cell walls by animals. Nature 406, 36-37.

  • Email: info@hutton.ac.uk
  • Phone: +44 (0)844 928 5428
  • Craigiebuckler Aberdeen AB15 8QH Scotland
  • Invergowrie Dundee DD2 5DA Scotland
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Registered office: The James Hutton Institute, Invergowrie Dundee DD2 5DA. Charity No SCO41796

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The James Hutton Research Institute is the result of the merger in April 2011 of MLURI and SCRI. This merger formed a new powerhouse for research into food, land use, and climate change.