Gordon McDougall
Current research interests
There is increasing evidence that non-nutrient components of fruit and vegetables (FAV) may have key roles in providing the health benefits associated with diets rich in FAV. The main thrust of my research examines the possibility that phytochemicals in plant foods can influence human health. The focus has been on soft fruit, particularly on polyphenols in berries, as there is already evidence for the effectiveness of these components from other foods and beverages and berries are a particularly rich and palatable source.
My research has four main overlapping and interdependent areas:
- Establishment of bioactivities relevant to human health for berry polyphenols
- Analysis of the composition of polyphenols in bioactive extracts to confirm structure-activity relationships for effectiveness and to assess the stability and bioavailability of active components in the human body
- Development of high through-put methods to analyse the inheritance of bioactive polyphenols in berries, to link the ‘health' phenotype to the genotype of The James Hutton Institute’s elite germplasm collection.
- Assess environmental influences on the accumulation of levels of bioactive components.
To accrue evidence that berry phytochemicals have bioactivities that can influence human health or mitigate disease progression, I have initiated collaborations with a range of biomedical experts who have relevant model systems for cardiovascular health, neurodegeneration, diabetes, and cancers. These model systems range from in vitro enzyme screens, ex vitro cell or tissue studies to animal or human trials. I also developed key in-house screens and assays. In each case, extracts with closely defined compositions have been used and the studies include analysis of the metabolic fate of the components to define the mechanisms of action and the candidate active ingredients. In human trials, bioavailability studies of the levels of metabolites in blood, urine and faeces have been completed.
Through these studies, I have confirmed that different polyphenol components from berries can have different effects in different model systems and that overall efficacy is often decided by a combination of bioactivity, stability and longevity/bioavailability in the system. These cross-disciplinary collaborations have led to close associations particularly with the University of Ulster and the University of Dundee. These approaches are currently being applied to studies on Alzheimer’s disease through the EU-funded BrainHealthFood project.
Along with Ilka Abreu and Sean Connor, I have established novel MS based methods for following polyphenol diversity. This has enabled us to begin to link polyphenol inheritance to the genetic maps being developed for raspberry and blackcurrant by the Genetics Programme (with Rex Brennan and Julie Graham). Through this approach, we hope to enable accelerated breeding of improved varieties with elevated levels of healthy components. Importantly, I have also directed research to establish if environmental conditions influence polyphenol levels, which has informed us that certain genetic markers are consistently associated with enhanced polyphenol content across years with widely differing climatic conditions. The high-through-put methods developed have been employed to track the diversity of polyphenols from growing berries under different agronomic conditions, in different latitudes or after different processing methods with collaborators from across Europe (ClimaFruit Project). These areas form part of the new programme of work planned for the Scottish Government.
Past research
I have also been involved in studies that correlate the metabolic and molecular changes associated with aspects of food quality. For example, through close working with Mark Taylor and Rob Hancock and collaborators from the University of Colorado, we correlated changes in metabolite profiles and gene expression in coloured and non-coloured potato tuber tissues.
With industrial and University partners, I have applied our analytical capacities to solve problems associated with berry flavour, juice manufacture and the effects of processing and cooking on bioactive components from diverse sources such as seaweeds and oats (see Quoats project).
I have also applied expertise in cell wall chemistry and biochemistry to studies on potato flavour and texture led by Mark Taylor within PPFQ. We are assessing the genetic and biochemical basis of potato tuber texture by comparing differences in textural properties between Solanum tuberosum and Solanum phureja varieties. These varieties have consistent year-on-year differences in texture and cooking properties, which are correlated with differences in cell wall structure and cohesiveness. We have identified that these differences are mainly associated with subtle differences in pectin structure and localisation which directly influence cell-to-cell adhesion. Indeed, microarray analysis has identified candidate genes involved in pectin methylation and decoration whose expression has subsequently been manipulated to provide evidence for their involvement in the textural traits.
This work has involved collaborations with British Universities including Bath, Glasgow, Ulster, Dundee, Reading, Abertay, Queen Margaret, Newcastle, Sheffield Hallam, Strathclyde, Aberystwyth, University of the Highlands and Islands and St Andrews. International collaborations are in place with scientists from Universities and Research Institutes in, for example, Germany, Italy, Bulgaria, Spain, Norway, Sweden, Denmark, France, Holland, Ireland, Portugal, USA and New Zealand. We also have a number of research partners in UK and European companies.
Bibliography
- C. Biancacci; G. J. McDougall; J. W. Allwood; J. G. Day; K. Davidson & M. S. Stanley (2021) LC-MSn profiling reveals seasonal variation in the composition of Osmundea pinnatifida (Hudson) Stackhouse, Journal of Applied Phycology, 33, 2443-2458.
- Lima, R.C.L.; Böcker, U.; McDougall, G.J.; Allwood, J.W.; Afseth, N.K.; Wubshet, S.G. (2021) Magnetic ligand fishing using immobolized DPP-IV for identification of antidiabetic ligands in lingonberry extract., PLoS ONE, Article No. e0247329.
- Banda, L.; Moyo, M.; Nakitto, M.; Swanckaert, J.; Onyango, A.; Magiri, E.; McDougall, G.J.; Ducreux, L.J.M.; Taylor, M.; Muzhingi, T. (2021) Application of wedge fracture test for texture analysis in boiled Sweetpotato (Ipomoea batatas)., African Journal of Food Science, 15, 145-151.
- Dobani, S.; Latimer, C.; McDougall, G.J.; Allwood, J.W.; Pereira-Caro, G.; Moreno-Rojas, J.M.; Ternan, N.G.; Pourshahidi, L.K.; Lawther, R.; Tuohy, K.M.; Del Rio; D.; O’Connor, G.; Rowland, I.; Almutairi, M.T.; Crozier, A.; Gill, C.I.R. (2021) Ex vivo fecal fermentation of human ileal fluid collected after raspberry consumption modifies (poly)phenolics and modulates genoprotective effects in colonic epithelial cells., Redox Biology, 40, Article No. 101862.
- Abukhabta, S,; Ghawi, S.K.; Karatzas, K.A.; Charalampopoulos, D.; McDougall, G.; Allwood, J.W.; Verrall, S.; Lavery, S.; Latimer, C.; Pourshahidi, K.; Lawther, R.; O’Connor, G.; Rowland, I.; Gil, C.I.R. (2021) Sulforaphane-enriched extracts from glucoraphanin-rich broccoli exert antimicrobial activity against gut pathogens in vitro and innovative cooking methods increase in vivo intestinal delivery of sulforphane., European Journal of Nutrition, 60, 1263-1276.
- Garcia, G.; Pais, T.F.; Pinto, P.; Dobson, G.; McDougall, G.J.; Stewart, D.; Santos, C.N. (2020) Bioaccessible raspberry extracts enriched in ellagitannins and ellagic acid derivatives have anti-neuroinflammatory properties., Antioxidants, 9, Article No. 970.
- Matos, M.S.; Anastácio, J.D.; Allwood, J.W.; Carregosa, D.; Marques, D.; Sungurtas, J.; McDougall, G.J.; Menezes, R.; Matias, A.A.; Stewart, D.; Nunes dos Santos, C. (2020) Assessing the intestinal permeability and anti-inflammatory potential of sesquiterpene lactones from chicory., Nutrients, 12, Article No. 3547.
- Allwood, J.W.; Evans, H.; Austin, C.; McDougall, G.J. (2020) Extraction, enrichment, and LC-MSn-based characterization of phlorotannins and related phenolics from the brown seaweed, Ascophyllum nodosum., Marine Drugs, 18, Article No. 448.
- Kay, C.D.; Clifford, M.N.; Mena, P.; McDougall, G.J.; Andres-Lacueva, C.; Cassidy, A.; Del Rio, D.; Kuhnert, N.; Manach, C.; Pereira-Caro, G.; Rodriguez-Mateos, A.M.; Scalbert, A.; Barberán, F.T.; Williamson, G.; Wishart, D.S.; Crozier, A. (2020) Recommendations for standardizing nomenclature for dietary (poly)phenol catabolites., American Journal of Clinical Nutrition, 112, 1051-1068.
- Koper, J.E.B.; Kortekaas, M.; Loonen, L.M.P.; Huang, Z.; Wells, J.M.; Gill, C.I.R.; Pourshahidi, L.K.; McDougall, G.; Rowland, I.; Pereira-Caro, G.; Fogliano, V.; Capuano, E. (2020) Aryl hydrocarbon receptor activation during in vitro and in vivo digestion of raw and cooked broccoli (brassica oleracea var.Italica)., Food and Function, 11, 4026-4037.
- Abreu, I.N.; Brennan, R.M.; Kanichukattu, E.N.; Stewart, D.; Hancock, R.D.; McDougall, G.J.; Hackett, C.A. (2020) Quantitative trait loci mapping of polyphenol metabolites in blackcurrant (Ribes nigrum)., Metabolomics, 16, Article No.25.
- McDougall, G.J.; Foito, A.; Dobson, G.; Austin, C.; Sungartas, J.; Su, S.; Wang, L.; Feng, C.; Li, S.; Wang, L.; Wei, W.; Allwood, J.W.; Stewart, D. (2020) Glutathionyl-S-chlorogenic acid is present in fruit of Vaccinium species, potato tubers and apple juice., Food Chemistry, 330, Article No. 127227.
- Hayward, N.J.; McDougall, G.J.; Farag, S.; Allwood, J.W.; Austin, C.; Campbell, F.; Horgan, G.; Ranawana, V. (2019) Cinnamon shows antidiabetic properties that are species-specific: effects on enzyme activity inhibition and starch digestion., Plant Foods for Human Nutrition, 74, 544-552.
- Watson, A.W.; Okello, E.J.; Brooker, H.J.; Lester, S.; McDougall, G.J.; Wesnes, K.A. (2019) The impact of blackcurrant juice on attention, mood and brain wave spectral activity in young healthy volunteers., Nutritional Neuroscience, 22, 596-606.
- Figueira, I.; Tavares, L.; Jardim, C.; Costa, I.; Terrasso, A.P.; Almeida, A.F.; Govers, C.C.F.M.; Mes, J.J.; Gardner, R.; Becker, J.D.; McDougall, G.J.; Stewart, D.; Filipe, A.; Kim, K.S.; Brites, D.; Brito, C.; Brito, M.A.; Santos, C.N. (2019) Blood-brain barrier permeability and neuroprotective potential of blackberry-digested polyphenols., European Journal of Nutrition, 58, 113-130.
- McDougall, G.J. (2019) The potential role of polyphenol-enzyme interactions on human health., In: Varelis, P., Melton, L. & Shahidi, F. (eds.). Melton, L., Encyclopedia of Food Chemistry, Elsevier Reference Work, Volume 2, pp578-582.
- Bonar, N.; Liney, M.; Zhang, R.X.; Austin, C.; Dessoly, J.; Davidson, D.; Stephens, J.; McDougall, G.; Taylor, M.; Bryan, G.J.; Hornyik, C. (2018) Potato miR828 is associated with purple tuber skin and flesh colour., Frontiers in Plant Sciences, 9, Article No. 1742.
- Logie, L.; Lees, Z.; Allwood, J.W.; McDougall, G.J.; Beall, C.; Rena, G. (2018) Regulation of hepatic glucose production and AMPK by AICAR but not by metformin depends on drug uptake through the equilibrative nucleoside transporter 1 (ENT1)., Diabetes, Obesity and Metabolism, 20, 2748-2758.
- Ternan, N.G.; Moore, N.D.; Smyth, D.; McDougall, G.J.; Allwood, J.W.; Verrall, S.; Gill, C.I.R.; Dooley, J.S.G.; McMullan, G. (2018) Increased sporulation underpins adaptation of Clostridium difficile strain 630 to a biologically-relevant faecal environment, with implications for pathogenicity., Scientific Reports, 8, Article No. 16691.
- Tsang, C.; Smail, N.F.; Al-Moosawi, S.; McDougall, G.J.; Al-Dujaili, E.A.S. (2018) Antioxidant rich potato improves arterial stiffness in healthy adults., Plant Foods for Human Nutrition, 73, 203-208.
- Macedo, D.; Jardim, C.; Figueira, I.; Almeida, A.F.; McDougall, G.J.; Stewart, D.; Yuste, J.E.; Tomás-Barberán, F.A.; Tenreiro, S.; Outeiro, T.F.; Santos, C.N. (2018) (Poly)phenol-digested metabolites modulate alpha-synuclein toxicity by regulating proteostasis., Scientific Reports, 8, Article No. 6965.
- Cameron, A.; Logie, L.; Patel, K.; Erhardt, S.; Bacon, S.; Middleton, P.; Harthill, J.; Forteath, C.; Coats, J.T.; Kerr, C.; Curry, H.; Stewart, D.; Sakamoto, K.; Repiscák, P.; Paterson, M.J.; Hassinen, I.; McDougall, G.J.; Rena, G. (2018) Metformin selectively targets redox control of complex I energy transduction., Redox Biology, 14, 187-197.
- Austin, C.; Stewart, D.; Allwood, J.W.; McDougall, G.J. (2018) Extracts from the edible seaweed, Ascophyllum nodosum, inhibit lipase activity in vitro: contributions of phenolic and polysaccharide components., Food and Function, 9, 502-510.
- Patras, M.A.; Jaiswal, R.; McDougall, G.J.; Kuhnert, N. (2018) Profiling and quantification of regioisomeric caffeoyl glucoses in berry fruits., Journal of Agricultural and Food Chemistry, 66, 1096-1104.
- Giampieri, F.; Afrin, S.; Stewart, D.; McDougall, G.J.; Brennan, R.; Blyth, L.; Gasparrini, M.; Mazzoni, L.; Capocasa, F.; Alvarez-Suarez, J.M.; Bompadre, S.; de Oliveira, P.N.B.; Santos, C.N.; Masias, M.; Agudo, P.; Crespo, J.; Mezzetti, B.; Forbes-Hernandez, T.Y.; Battino, M. (2018) Phytochemical composition and cytotoxic effects on liver hepatocellular carcinoma cells of different berries following a simulated in vitro gastrointestinal digestion., Molecules, 23, Article No. 1918.
- Hancock, R.D.; Petridis, A.; McDougall, G.J. (2018) Raspberry fruit chemistry in relation to fruit quality and human nutrition., In: Graham, J. & Brennan, R. (eds.). Raspberry. Springer Nature, Cham, Switzerland, Chapter 7, pp89-119
- Foito, A.; McDougall, G.J.; Stewart, D. (2018) Evidence for health benefits of berries., Annual Plant Reviews, No.1, April 2018.
- Bishimbayeva, N.K.; Murtazina, A.S.; McDougall, G.J. (2017) Influence of phytohormones on monosaccharide composition of polysaccharides from wheat suspension cultures., Eurasian Chemico-Technological Journal, 19, 231-237.
- Stockton, A.; Farhat, G.; McDougall, G.J.; Al-Dujaili, E.A.S. (2017) Effect of pomegranate extract on blood pressure and anthropometry in adults: a double-blind placebo-controlled randomised clinical trial., Journal of Nutritional Science, 6, Article No. e39.
- Figueira, I.; Garcia, G.; Pimpão, R.C.; Terrasso, A.P.; Costa, I.; Almeida, A.F.; Tavares, L.; Pais, T.F.; Pinto, P.; Ventura, M.; Filipe, A.; McDougall, G.J.; Stewart, D.; Kim, K.S.; Palmela, I.; Brites, D.; Brito, M.A.; Brito, C.; Santos, C.N. (2017) Polyphenols journey through blood-brain barrier towards neuronal protection., Scientific Reports, 7, Article No. 11456.
- McDougall, G.J.; Allwood, J.W.; Pereira-Caro, G.; Brown, E.M.; Latimer, C.; Dobson, G.; Stewart, D.; Ternan, N.G.; Lawther, R.; O'Connor, G.; Rowland, I.; Crozier, A.; Gill, C.I.R. (2017) The composition of potentially bioactive triterpenoid glycosides in red raspberry is influenced by tissue, extraction procedure and genotype., Food and Function, 8, 3469-3479.
- Fyfe, L.; Okoro, P.; Paterson, E.; Coyle, S.; McDougall, G.J. (2017) Compositional analysis of Scottish honeys with antimicrobial activity against antibiotic-resistant bacteria reveals novel antimicrobial components., LWT - Food Science and Technology, 79, 52-59.
- Jardim, C.; Macedo, D.; Figueira, I.; Dobson, G.; McDougall, G.J.; Stewart, D.; Ferreira, R.B.; Menezes, R.; Santos, C.N. (2017) (Poly)phenol metabolites from Arbutus unedo leaves protect yeast from oxidative injury by activation of antioxidant and protein clearance pathways., Journal of Functional Foods, 32, 333-346.
- Kårlund, A.; Hanhineva, K.; Lehtonen, M.; McDougall, G.J.; Stewart, D.; Karjalainen, R.O. (2017) Non-targeted metabolite profiling highlights the potential of strawberry leaves as a resource for specific bioactive compounds., Journal of the Science of Food and Agriculture, 97, 2182-2190.
- McDougall, G.J.; Allwood, J.W.; Pereira-Caro, G.; Brown, E.M.; Verrall, S.; Stewart, D.; Latimer, C.; McMullan, G.; Lawther, R.; O'Connor, G.; Rowland, I.; Crozier, A.; Gill, C.I.R. (2017) Novel colon-available triterpenoids identified in raspberry fruits exhibit antigenotoxic activities in vitro., Molecular Nutrition and Food Research, 61, Article No. 1600327.
- Butler, T.O.; McDougall, G.J.; Campbell, R.; Stanley, M.S.; Day, J.G. (2017) Media screening for obtaining Haematococcus pluvialis red motile macrozooids rich in astaxanthin and fatty acids., Biology, 7, Article No. 2.
- Garcia, G.; Nanni, S.; Figueira, I.; Ivanov, I.; McDougall, G.J.; Stewart, D.; Ferreira, R.B.; Pinto, P.; Silva, R.F.M.; Brites, D.; Santos, C.N. (2017) Bioaccessible (poly)phenol metabolites from raspberry protect neural cells from oxidative stress and attenuate microglia activation., Food Chemistry, 215, 274-283.
- Dobson, G.; McDougall, G.J.; Stewart, D.; Cubero, M.A.; Karjalainen, R.O. (2017) Effects of juice matrix and pasteurization on stability of black currant anthocyanins during storage., Journal of Food Science, 82, 44-52.
- McDougall, G.J. (2017) Phenolic-enriched foods: sources and processing for enhanced benefits., Proceedings of the Nutrition Society, 76, 163-171.
- Kårlund, A.; Moor, U.; McDougall, G.; Lehtonen, M.; Karjalainen, R.O.; Hanhineva, K. (2016) Metabolic profiling discriminates between strawberry (Fragaria x ananassa Duch.) cultivars grown in Finland or Estonia., Food Research International, 89, 647-653.
- C. Biancacci; G. J. McDougall; J. W. Allwood; J. G. Day; K. Davidson & M. S. Stanley (2021) LC-MSn profiling reveals seasonal variation in the composition of Osmundea pinnatifida (Hudson) Stackhouse, Journal of Applied Phycology, 33, 2443-2458.
- Lima, R.C.L.; Böcker, U.; McDougall, G.J.; Allwood, J.W.; Afseth, N.K.; Wubshet, S.G. (2021) Magnetic ligand fishing using immobolized DPP-IV for identification of antidiabetic ligands in lingonberry extract., PLoS ONE, Article No. e0247329.
- Banda, L.; Moyo, M.; Nakitto, M.; Swanckaert, J.; Onyango, A.; Magiri, E.; McDougall, G.J.; Ducreux, L.J.M.; Taylor, M.; Muzhingi, T. (2021) Application of wedge fracture test for texture analysis in boiled Sweetpotato (Ipomoea batatas)., African Journal of Food Science, 15, 145-151.
- Dobani, S.; Latimer, C.; McDougall, G.J.; Allwood, J.W.; Pereira-Caro, G.; Moreno-Rojas, J.M.; Ternan, N.G.; Pourshahidi, L.K.; Lawther, R.; Tuohy, K.M.; Del Rio; D.; O’Connor, G.; Rowland, I.; Almutairi, M.T.; Crozier, A.; Gill, C.I.R. (2021) Ex vivo fecal fermentation of human ileal fluid collected after raspberry consumption modifies (poly)phenolics and modulates genoprotective effects in colonic epithelial cells., Redox Biology, 40, Article No. 101862.
- Abukhabta, S,; Ghawi, S.K.; Karatzas, K.A.; Charalampopoulos, D.; McDougall, G.; Allwood, J.W.; Verrall, S.; Lavery, S.; Latimer, C.; Pourshahidi, K.; Lawther, R.; O’Connor, G.; Rowland, I.; Gil, C.I.R. (2021) Sulforaphane-enriched extracts from glucoraphanin-rich broccoli exert antimicrobial activity against gut pathogens in vitro and innovative cooking methods increase in vivo intestinal delivery of sulforphane., European Journal of Nutrition, 60, 1263-1276.
- Garcia, G.; Pais, T.F.; Pinto, P.; Dobson, G.; McDougall, G.J.; Stewart, D.; Santos, C.N. (2020) Bioaccessible raspberry extracts enriched in ellagitannins and ellagic acid derivatives have anti-neuroinflammatory properties., Antioxidants, 9, Article No. 970.
- Matos, M.S.; Anastácio, J.D.; Allwood, J.W.; Carregosa, D.; Marques, D.; Sungurtas, J.; McDougall, G.J.; Menezes, R.; Matias, A.A.; Stewart, D.; Nunes dos Santos, C. (2020) Assessing the intestinal permeability and anti-inflammatory potential of sesquiterpene lactones from chicory., Nutrients, 12, Article No. 3547.
- Allwood, J.W.; Evans, H.; Austin, C.; McDougall, G.J. (2020) Extraction, enrichment, and LC-MSn-based characterization of phlorotannins and related phenolics from the brown seaweed, Ascophyllum nodosum., Marine Drugs, 18, Article No. 448.
- Kay, C.D.; Clifford, M.N.; Mena, P.; McDougall, G.J.; Andres-Lacueva, C.; Cassidy, A.; Del Rio, D.; Kuhnert, N.; Manach, C.; Pereira-Caro, G.; Rodriguez-Mateos, A.M.; Scalbert, A.; Barberán, F.T.; Williamson, G.; Wishart, D.S.; Crozier, A. (2020) Recommendations for standardizing nomenclature for dietary (poly)phenol catabolites., American Journal of Clinical Nutrition, 112, 1051-1068.
- Koper, J.E.B.; Kortekaas, M.; Loonen, L.M.P.; Huang, Z.; Wells, J.M.; Gill, C.I.R.; Pourshahidi, L.K.; McDougall, G.; Rowland, I.; Pereira-Caro, G.; Fogliano, V.; Capuano, E. (2020) Aryl hydrocarbon receptor activation during in vitro and in vivo digestion of raw and cooked broccoli (brassica oleracea var.Italica)., Food and Function, 11, 4026-4037.
- Abreu, I.N.; Brennan, R.M.; Kanichukattu, E.N.; Stewart, D.; Hancock, R.D.; McDougall, G.J.; Hackett, C.A. (2020) Quantitative trait loci mapping of polyphenol metabolites in blackcurrant (Ribes nigrum)., Metabolomics, 16, Article No.25.
- McDougall, G.J.; Foito, A.; Dobson, G.; Austin, C.; Sungartas, J.; Su, S.; Wang, L.; Feng, C.; Li, S.; Wang, L.; Wei, W.; Allwood, J.W.; Stewart, D. (2020) Glutathionyl-S-chlorogenic acid is present in fruit of Vaccinium species, potato tubers and apple juice., Food Chemistry, 330, Article No. 127227.
- Hayward, N.J.; McDougall, G.J.; Farag, S.; Allwood, J.W.; Austin, C.; Campbell, F.; Horgan, G.; Ranawana, V. (2019) Cinnamon shows antidiabetic properties that are species-specific: effects on enzyme activity inhibition and starch digestion., Plant Foods for Human Nutrition, 74, 544-552.
- Watson, A.W.; Okello, E.J.; Brooker, H.J.; Lester, S.; McDougall, G.J.; Wesnes, K.A. (2019) The impact of blackcurrant juice on attention, mood and brain wave spectral activity in young healthy volunteers., Nutritional Neuroscience, 22, 596-606.
- Figueira, I.; Tavares, L.; Jardim, C.; Costa, I.; Terrasso, A.P.; Almeida, A.F.; Govers, C.C.F.M.; Mes, J.J.; Gardner, R.; Becker, J.D.; McDougall, G.J.; Stewart, D.; Filipe, A.; Kim, K.S.; Brites, D.; Brito, C.; Brito, M.A.; Santos, C.N. (2019) Blood-brain barrier permeability and neuroprotective potential of blackberry-digested polyphenols., European Journal of Nutrition, 58, 113-130.
- Bonar, N.; Liney, M.; Zhang, R.X.; Austin, C.; Dessoly, J.; Davidson, D.; Stephens, J.; McDougall, G.; Taylor, M.; Bryan, G.J.; Hornyik, C. (2018) Potato miR828 is associated with purple tuber skin and flesh colour., Frontiers in Plant Sciences, 9, Article No. 1742.
- Logie, L.; Lees, Z.; Allwood, J.W.; McDougall, G.J.; Beall, C.; Rena, G. (2018) Regulation of hepatic glucose production and AMPK by AICAR but not by metformin depends on drug uptake through the equilibrative nucleoside transporter 1 (ENT1)., Diabetes, Obesity and Metabolism, 20, 2748-2758.
- Ternan, N.G.; Moore, N.D.; Smyth, D.; McDougall, G.J.; Allwood, J.W.; Verrall, S.; Gill, C.I.R.; Dooley, J.S.G.; McMullan, G. (2018) Increased sporulation underpins adaptation of Clostridium difficile strain 630 to a biologically-relevant faecal environment, with implications for pathogenicity., Scientific Reports, 8, Article No. 16691.
- Tsang, C.; Smail, N.F.; Al-Moosawi, S.; McDougall, G.J.; Al-Dujaili, E.A.S. (2018) Antioxidant rich potato improves arterial stiffness in healthy adults., Plant Foods for Human Nutrition, 73, 203-208.
- Macedo, D.; Jardim, C.; Figueira, I.; Almeida, A.F.; McDougall, G.J.; Stewart, D.; Yuste, J.E.; Tomás-Barberán, F.A.; Tenreiro, S.; Outeiro, T.F.; Santos, C.N. (2018) (Poly)phenol-digested metabolites modulate alpha-synuclein toxicity by regulating proteostasis., Scientific Reports, 8, Article No. 6965.
- Cameron, A.; Logie, L.; Patel, K.; Erhardt, S.; Bacon, S.; Middleton, P.; Harthill, J.; Forteath, C.; Coats, J.T.; Kerr, C.; Curry, H.; Stewart, D.; Sakamoto, K.; Repiscák, P.; Paterson, M.J.; Hassinen, I.; McDougall, G.J.; Rena, G. (2018) Metformin selectively targets redox control of complex I energy transduction., Redox Biology, 14, 187-197.
- Austin, C.; Stewart, D.; Allwood, J.W.; McDougall, G.J. (2018) Extracts from the edible seaweed, Ascophyllum nodosum, inhibit lipase activity in vitro: contributions of phenolic and polysaccharide components., Food and Function, 9, 502-510.
- Patras, M.A.; Jaiswal, R.; McDougall, G.J.; Kuhnert, N. (2018) Profiling and quantification of regioisomeric caffeoyl glucoses in berry fruits., Journal of Agricultural and Food Chemistry, 66, 1096-1104.
- Giampieri, F.; Afrin, S.; Stewart, D.; McDougall, G.J.; Brennan, R.; Blyth, L.; Gasparrini, M.; Mazzoni, L.; Capocasa, F.; Alvarez-Suarez, J.M.; Bompadre, S.; de Oliveira, P.N.B.; Santos, C.N.; Masias, M.; Agudo, P.; Crespo, J.; Mezzetti, B.; Forbes-Hernandez, T.Y.; Battino, M. (2018) Phytochemical composition and cytotoxic effects on liver hepatocellular carcinoma cells of different berries following a simulated in vitro gastrointestinal digestion., Molecules, 23, Article No. 1918.
- Bishimbayeva, N.K.; Murtazina, A.S.; McDougall, G.J. (2017) Influence of phytohormones on monosaccharide composition of polysaccharides from wheat suspension cultures., Eurasian Chemico-Technological Journal, 19, 231-237.
- Stockton, A.; Farhat, G.; McDougall, G.J.; Al-Dujaili, E.A.S. (2017) Effect of pomegranate extract on blood pressure and anthropometry in adults: a double-blind placebo-controlled randomised clinical trial., Journal of Nutritional Science, 6, Article No. e39.
- Figueira, I.; Garcia, G.; Pimpão, R.C.; Terrasso, A.P.; Costa, I.; Almeida, A.F.; Tavares, L.; Pais, T.F.; Pinto, P.; Ventura, M.; Filipe, A.; McDougall, G.J.; Stewart, D.; Kim, K.S.; Palmela, I.; Brites, D.; Brito, M.A.; Brito, C.; Santos, C.N. (2017) Polyphenols journey through blood-brain barrier towards neuronal protection., Scientific Reports, 7, Article No. 11456.
- McDougall, G.J.; Allwood, J.W.; Pereira-Caro, G.; Brown, E.M.; Latimer, C.; Dobson, G.; Stewart, D.; Ternan, N.G.; Lawther, R.; O'Connor, G.; Rowland, I.; Crozier, A.; Gill, C.I.R. (2017) The composition of potentially bioactive triterpenoid glycosides in red raspberry is influenced by tissue, extraction procedure and genotype., Food and Function, 8, 3469-3479.
- Fyfe, L.; Okoro, P.; Paterson, E.; Coyle, S.; McDougall, G.J. (2017) Compositional analysis of Scottish honeys with antimicrobial activity against antibiotic-resistant bacteria reveals novel antimicrobial components., LWT - Food Science and Technology, 79, 52-59.
- Jardim, C.; Macedo, D.; Figueira, I.; Dobson, G.; McDougall, G.J.; Stewart, D.; Ferreira, R.B.; Menezes, R.; Santos, C.N. (2017) (Poly)phenol metabolites from Arbutus unedo leaves protect yeast from oxidative injury by activation of antioxidant and protein clearance pathways., Journal of Functional Foods, 32, 333-346.
- Kårlund, A.; Hanhineva, K.; Lehtonen, M.; McDougall, G.J.; Stewart, D.; Karjalainen, R.O. (2017) Non-targeted metabolite profiling highlights the potential of strawberry leaves as a resource for specific bioactive compounds., Journal of the Science of Food and Agriculture, 97, 2182-2190.
- McDougall, G.J.; Allwood, J.W.; Pereira-Caro, G.; Brown, E.M.; Verrall, S.; Stewart, D.; Latimer, C.; McMullan, G.; Lawther, R.; O'Connor, G.; Rowland, I.; Crozier, A.; Gill, C.I.R. (2017) Novel colon-available triterpenoids identified in raspberry fruits exhibit antigenotoxic activities in vitro., Molecular Nutrition and Food Research, 61, Article No. 1600327.
- Butler, T.O.; McDougall, G.J.; Campbell, R.; Stanley, M.S.; Day, J.G. (2017) Media screening for obtaining Haematococcus pluvialis red motile macrozooids rich in astaxanthin and fatty acids., Biology, 7, Article No. 2.
- Garcia, G.; Nanni, S.; Figueira, I.; Ivanov, I.; McDougall, G.J.; Stewart, D.; Ferreira, R.B.; Pinto, P.; Silva, R.F.M.; Brites, D.; Santos, C.N. (2017) Bioaccessible (poly)phenol metabolites from raspberry protect neural cells from oxidative stress and attenuate microglia activation., Food Chemistry, 215, 274-283.
- Dobson, G.; McDougall, G.J.; Stewart, D.; Cubero, M.A.; Karjalainen, R.O. (2017) Effects of juice matrix and pasteurization on stability of black currant anthocyanins during storage., Journal of Food Science, 82, 44-52.
- McDougall, G.J. (2017) Phenolic-enriched foods: sources and processing for enhanced benefits., Proceedings of the Nutrition Society, 76, 163-171.
- Kårlund, A.; Moor, U.; McDougall, G.; Lehtonen, M.; Karjalainen, R.O.; Hanhineva, K. (2016) Metabolic profiling discriminates between strawberry (Fragaria x ananassa Duch.) cultivars grown in Finland or Estonia., Food Research International, 89, 647-653.
- Brown, E.; Gill, C.; Stewart, D.; McDougall, G. (2016) Lingonberries (Vaccinium vitis-idaea L) and blueberries (Vaccinium corymbosum) contain discrete epicatechin anthocyanin derivatives linked by ethyl bridges., Journal of Berry Research, 6, 13-23.
- Cameron, A.R.; Logie, L.; Patel, K.; Bacon, S.; Forteath, C.; Harthill, J.; Roberts, A.; Sutherland, C.D.; Stewart, D.; Viollet, B.; Sakamoto, K.; McDougall, G.; Foretz, M.; Rena, G. (2016) Investigation of salicylate hepatic responses in comparison with chemical analogues of the drug., Biochimica et Biophysica Acta - Molecular Basis of Disease, 1862, 1412-1422.
- McDougall, G.J.; Austin, C.; van Schayk, E.; Martin, P. (2016) Salal (Gaultheria shallon) and aronia (Aronia melanocarpa) fruits from Orkney: phenolic content, composition and effect of wine making., Food Chemistry, 205, 239-247.
- Logie, L.; Bacon, S.; Middleton, P.; Harthill, J.; Coats, J.; Stewart, D.; Sakamoto, K.; McDougall, G.; Rena, G. (2013) How does glucophage (metaformin) work? Investigation of the cellular action of chemical analogues., Diabetes UK Professional Conference, Manchester Central, Manchester, 13-15 March 2013.
- McDougall, G.J.; Dobson, P.; Jordan-Mahy, N. (2010) Effect of different cooking regimes on rhubarb polyphenols., Food Chemistry, 119, 758-764.
- McDougall, G.J. (2019) The potential role of polyphenol-enzyme interactions on human health., In: Varelis, P., Melton, L. & Shahidi, F. (eds.). Melton, L., Encyclopedia of Food Chemistry, Elsevier Reference Work, Volume 2, pp578-582.
- Hancock, R.D.; Petridis, A.; McDougall, G.J. (2018) Raspberry fruit chemistry in relation to fruit quality and human nutrition., In: Graham, J. & Brennan, R. (eds.). Raspberry. Springer Nature, Cham, Switzerland, Chapter 7, pp89-119
- Foito, A.; McDougall, G.J.; Stewart, D. (2018) Evidence for health benefits of berries., Annual Plant Reviews, No.1, April 2018.
- Taylor, M.A.; McDougall, G.J.; Stewart, D. (2007) Potato flavour and texture., In: Vreugdenhil, D., Bradshaw, J.E., Gebhardt, C., Govers, F., MacKerron, D.K.L. Taylor, M.A. & Ross, H.A. (eds.). Potato Biology and Biotechnology: Advances and Perspectives. Elsevier, Amsterdam, Chapter 24, pp525-540. ISBN: 978-0444510181
- McDougall, G.J. (2000) Cell-wall-associated proteins and wall biogenesis in developing compression and non-compression woods., In: Cell and Molecular Biology of Wood Formation (eds. R. Savidge, J.R. Barnett and R. Napier). SEB Experimental Biology Reviews. BIOS Scientific Publishers, Oxford, pp411-424.
- Richardson, A.; McDougall, G.J. (1998) Coniferyl alcohol oxidases as target enzymes for the genetic manipulation of lignin content in trees., In: Tree Biotechnology: Towards the Millennium (eds. M.R. Davey, P.G. Alderson, K.C. Lowe and J.B. Power). Nottingham University Press, pp301-313.
- Stewart, D.; McDougall, G. (2012) Potato: a nutritious, tasty but often maligned staple food., Commissioned Review for the Food and Health Innovation Service (FHIS).
- Stewart, D.; McDougall, G.J. (2012) The Brassicas - an undervalued nutritional and health beneficial plant family., Commissioned Review for the Food & Health Innovation Service (FHIS).
- McDougall, G.J.; Stewart, D. (2012) Berries and Health: A review of the evidence., Commissioned Review for the Food & Health Innovation Service (FHIS)
- Powell, C.; McDougall, G.J.; Hughes, A. (2011) Extraction and analysis of antioxidant pigments from sea urchin Psammechinus miliaris shells from intertidal and subtidal habitats., Nuffield Bursary Reports.
- Ross, H.A.; Morris, W.L.; Ducreux, L.J.M.; Hancock, R.D.; Verrall, S.R.; Morris, J.A.; Stewart, D.; Hedley, P.E.; McDougall, G.J.; Taylor, M.A. (2011) The role of pectin methyl esterase in determining potato tuber textural quality., Annual Report of the Scottish Crop Research Institute for 2010, pp32-33.
- McDougall, G.J.; Dobson, P. (2011) Antioxidant, polyphenol and vitamin C content of a novel juice mixture., Thomas Thomson (Blairgowrie) Ltd.
- McDougall, G.J.; Allison, F.; Dobson, P. (2010) Antioxidant capacity of potatoes: effect of processing and cooking., Albert Bartlett Website, 5pp.
- McDougall, G.J. (2010) Fruit components and their impact on fundamental disease mechanisims., Annual Report of the Scottish Crop Research Institute for 2009, pp29-30.
- Stewart, D.; McDougall, G.J.; Dobson, P. (2004) The relevance of soft fruit to human nutrition., Annual Report of the Scottish Crop Research Institute for 2003/2004, pp138-139.
- McDougall, G.J.; Ross, H.A.; Swanston, J.S.; Davies, H.V. (2004) A novel activity for a starch debranching enzyme., Annual Report of the Scottish Crop Research Institute for 2003/2004, pp142-143.
- MacKinnon, L.; McDougall, G.J.; Aziz, N.; Millam, S. (2001) Progress towards transformation of fibre hemp., Annual Report of the Scottish Crop Research Institute for 2000/2001, pp84-86.
- Richardson, A.; Deighton, N.; Duncan, J.A.; McDougall, G.J. (2000) Oxidases participate in the formation of wood., Annual Report of the Scottish Crop Research Institute for 1999/2000, pp129-131.
- McDougall, G.J.; Morrison, I.M.; Stewart, D.; Kerby, N.W. (1995) The potential for the establishment of a centre of excellence for industrial and energy crops in Tayside., A Feasibility Study Commissioned by Scottish Enterprise Tayside.
- Baty, A.; McDougall, G.J.; Stewart, D.; Weyers, J.R.B.; Morrison, I.M. (1994) Control of plant fibre quality: identification and characterisation of key enzymes in cell wall synthesis., Annual Report of the Scottish Crop Research Institute for 1993, pp73-77.