Julie Squires
Current research interests
- Currently I am investigating ‘Temporal Co-regulation of Pathogenesis in Phytophthora’, as part of a BBSRC IPA project involving Syngenta, in the laboratory of Steve Whisson and Paul Birch.
- This has followed on from research into Phytophthora effectors with David Cooke, also using SSR markers to examine populations of potato late blight. Detection of Phytophthora species in natural ecosystems with international collaborators, along with soft fruit Phytophthora species detection and control alongside the maintenance of the James Hutton Institute’s Phytophthora species collection.
- These together allow a rich look into the exciting world of Phytophthora for me.
Past research
- Having completed my PhD in 1995 entitled The influence of monovalent and divalent metal cations on growth and morphology in Candida species at The University of Dundee I joined SCRI in 1998 and was involved in the assessment of field trials for the Integrated Control of Raspberry Root Rot (P. fragariae var rubi) project.
- I have also developed and applied molecular diagnostics to plant disease through the use of PCR and TaqMan to detect, identify and quantify fungal and/or bacterial pathogens.
- For the Scottish Executive Micronet programme I investigated the scale of diversity amongst non culturable soil bacteria which are capable of nitrite reduction, and related these to the rhizosphere/rhizoplane of different grass species, and soil nutritional inputs, that is artificial sheep urine. Development of high throughput molecular methods-sequencing and T-RFLP were undertaken.
- In the world of plant viruses in the research group of Peter Palukaitis I studied to identify and characterise the potato RdRP-1 and IVR both implicated in potato viral resistance. I also investigated whether the use of the CaMV 35S promoter poses risks to the environment, through a DEFRA funded project examining the integration of viral sequences into plant genomes. The consequences of both viral infection on transgene expression and recombination between viruses and viral-based promoter elements in transgenic plants was also examined.
Other interests have included:
- Fruit breeding- in particular strawberry for tunnel production and processing markets.
- Use of the Commonwealth Potato collection to examine the interaction of the Phytophthora resistance gene family R3 with avirulence gene forms EM and KI to identify novel resistance genes.
Bibliography
- Ginetti, B.; Moricca, S.; Squires, J.N.; Cooke, D.E.L.; Ragazzi, A.; Jung, T., (2014) Phytophthora acerina sp. nov., a new species causing bleeding cankers and dieback of Acer pseudoplatanus trees in planted forests in northern Italy., Plant Pathology, 63, 858-876.
- Chowdappa, P.; Kumar, N.B.J.; Madhura, S.; Kumar, M.S.P.; Myers, K.L.; Fry, W.E.; Squires, J.N.; Cooke, D.E.L., (2013) Emergence of 13_A2 blue lineage of Phytophthora infestans was responsible for severe outbreaks of late blight on tomato in South-West India., Journal of Phytopathology, 161, 49-58.
- Cooke, D.E.L.; Cano, L.M.; Raffaele, S.; Bain, R.A.; Cooke, L.R.; Etherington, G.J.; Deahl, K.L.; Farrer, R.A.; Gilroy, E.M.; Goss, E.M.; Grunwald, N.J.; Hein, I.; Maclean, D.; McNicol, J.W.; Randall, E.; Oliva, R.F.; Pel, M.A.; Shaw, D.S.; Squires, J.N.; Taylor, M.C.; Vleeshouwers, V.G.A.A.; Birch, P.R.J.; Lees, A.K.; Kamoun, S., (2012) Genome analyses of an aggressive and invasive lineage of the Irish potato famine pathogen., PLoS Pathogens, 8, Article No. e1002940.
- Gilroy, E.M.; Breen, S.; Whisson, S.C.; Squires, J.; Hein, I.; Kaczmarek, M.; Turnbull, D.; Boevink, P.; Lokossou, A.; Cano, L.M.; Morales, J.; Avrova, A.O.; Pritchard, L.; Randall, E.; Lees, A.K.; Govers, F.; van West, P.; Kamoun, S.; Vleeshouwers, V.G.A.A.; Cooke, D.E.L.; Birch, P.R.J., (2011) Presence/absence, differential expression and sequence polmorphisms between PiAVR2 and PiAVR2-like in Phytophthora infestans determine virulence on R2 plants., New Phytologist, 191, 763-776.
- Squires, J.; Gillespie, T.; Schoelz, J.E.; Palukaitis, P., (2011) Excision and episomal replication of Cauliflower mosaic virus integrated into a plant genome., Plant Physiology, 155, 1908-1919.
- Rakhshanderhoo, F.; Takeshita, M.; Squires, J.; Palukaitis, P., (2009) The influence of RNA-dependent RNA polymerase 1 on Potato virus Y infection and on other antiviral response genes., Molecular Plant-Microbe Interactions, 22, 1312-1318.
- Squires, J.; Stephens, J.; Schoelz, J.E.; Palukaitis, P., (2007) Assessment of CaMV-mediated gene silencing and integration of CaMV into GM plants with a 35S RNA promoter., Environmental Biosafety Research, 6, 259-270.
- Palukaitis, P.; Squires, J., (2007) The insertion of cauliflower mosaic virus into host genomes during natural viral infections., Final Report to Defra, 56pp.
- Nunan, N.; Singh, B.; Reid, E.; Ord, B.; Papert, A.; Squires, J.; Prosser, J.; Wheateley, R.; McNicol, J.; Millard, P., (2006) Sheep urine deposition is a source of heterogeneity in upland grassland soil microbial community structure., FEMS Microbiology Ecology, 56, 310-320.
- Ginetti, B.; Moricca, S.; Squires, J.N.; Cooke, D.E.L.; Ragazzi, A.; Jung, T., (2014) Phytophthora acerina sp. nov., a new species causing bleeding cankers and dieback of Acer pseudoplatanus trees in planted forests in northern Italy., Plant Pathology, 63, 858-876.
- Chowdappa, P.; Kumar, N.B.J.; Madhura, S.; Kumar, M.S.P.; Myers, K.L.; Fry, W.E.; Squires, J.N.; Cooke, D.E.L., (2013) Emergence of 13_A2 blue lineage of Phytophthora infestans was responsible for severe outbreaks of late blight on tomato in South-West India., Journal of Phytopathology, 161, 49-58.
- Cooke, D.E.L.; Cano, L.M.; Raffaele, S.; Bain, R.A.; Cooke, L.R.; Etherington, G.J.; Deahl, K.L.; Farrer, R.A.; Gilroy, E.M.; Goss, E.M.; Grunwald, N.J.; Hein, I.; Maclean, D.; McNicol, J.W.; Randall, E.; Oliva, R.F.; Pel, M.A.; Shaw, D.S.; Squires, J.N.; Taylor, M.C.; Vleeshouwers, V.G.A.A.; Birch, P.R.J.; Lees, A.K.; Kamoun, S., (2012) Genome analyses of an aggressive and invasive lineage of the Irish potato famine pathogen., PLoS Pathogens, 8, Article No. e1002940.
- Gilroy, E.M.; Breen, S.; Whisson, S.C.; Squires, J.; Hein, I.; Kaczmarek, M.; Turnbull, D.; Boevink, P.; Lokossou, A.; Cano, L.M.; Morales, J.; Avrova, A.O.; Pritchard, L.; Randall, E.; Lees, A.K.; Govers, F.; van West, P.; Kamoun, S.; Vleeshouwers, V.G.A.A.; Cooke, D.E.L.; Birch, P.R.J., (2011) Presence/absence, differential expression and sequence polmorphisms between PiAVR2 and PiAVR2-like in Phytophthora infestans determine virulence on R2 plants., New Phytologist, 191, 763-776.
- Squires, J.; Gillespie, T.; Schoelz, J.E.; Palukaitis, P., (2011) Excision and episomal replication of Cauliflower mosaic virus integrated into a plant genome., Plant Physiology, 155, 1908-1919.
- Rakhshanderhoo, F.; Takeshita, M.; Squires, J.; Palukaitis, P., (2009) The influence of RNA-dependent RNA polymerase 1 on Potato virus Y infection and on other antiviral response genes., Molecular Plant-Microbe Interactions, 22, 1312-1318.
- Squires, J.; Stephens, J.; Schoelz, J.E.; Palukaitis, P., (2007) Assessment of CaMV-mediated gene silencing and integration of CaMV into GM plants with a 35S RNA promoter., Environmental Biosafety Research, 6, 259-270.
- Nunan, N.; Singh, B.; Reid, E.; Ord, B.; Papert, A.; Squires, J.; Prosser, J.; Wheateley, R.; McNicol, J.; Millard, P., (2006) Sheep urine deposition is a source of heterogeneity in upland grassland soil microbial community structure., FEMS Microbiology Ecology, 56, 310-320.
- Palukaitis, P.; Squires, J., (2007) The insertion of cauliflower mosaic virus into host genomes during natural viral infections., Final Report to Defra, 56pp.
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