Malcolm Macaulay
Current research interests
- Studying patterns of genetic variation shown by elite barley cultivars and the use of this information to gain insights into the control of characters of economic, agronomic and environmental importance.
- Characterisation of agronomically important genes.
- High throughput SNP genotyping using Illumina beadxpress platform using GoldenGate and Allele Specific Primer Extenstion assays on a number of plant species.
- Supervision, training and management associated with Genome Technology
- Support for genotypers at The James Hutton Institute, including trouble shooting software, hardware and technical issues.
Past research
- Biochemical and molecular marker development and utilisation in barley.
Bibliography
- Colas, I.; Barakate, A.; Macaulay, M.; Schreiber, M.; Stephens, J.; Vivera, S.; Halpin, C.; Waugh, R.; Ramsay, L. (2019) Desynaptic5 carries a spontaneous semi-dominant mutation affecting Disrupted Meiotic cDNA 1 (DMC1) in barley., Journal of Experimental Botany, 70, 2683-2698.
- Looseley, M.E.; Griffe, L.L.; Büttner, B.; Wright, K.M.; Middlefell-Williams, J.; Bull, H.; Shaw, P.D.; Macaulay, M.; Booth, A.; Schweizer, G.; Russell, J.R.; Waugh, R.; Thomas, W.T.B.; Avrova, A. (2018) Resistance to Rhynchosporium commune in a collection of European spring barley germplasm., Theoretical and Applied Genetics, 131, 2513-2528.
- Castro, A.J.; Cuesta-Marcos, A.; Hayes, P.M.; Locatelli, A.; Macaulay, M.; Mastandrea, N.; Silveira, M.; Thomas, W.T.B.; Viega, L. (2017) The completely additive effects of two barley phenology-related genes (eps2S and sdw1) are explained by specific effects at different periods within the crop growth cycle., Plant Breeding, 136, 663-670.
- Bayer, M.; Ganal, M.; Hedley, P.E.; Macaulay, M.; Plieske, J.; Ramsay, L.; Rapazote-Flores, P.; Russell, J.; Shaw, P.; Thomas, W.; Waugh, R. (2017) Development and evaluation of a barley 50k iSelect SNP array., Frontiers in Plant Science, 8, Article No. 1792.
- Liller, C.B.; Walla, A.; Boer, M.P.; Hedley, P.; Macaulay, M.; Effgen, S.; von Korff, M.; van Esse, G.W.; Koornneef, M. (2017) Fine mapping of a major QTL for awn length in barley using a multiparent mapping population., Theoretical and Applied Genetics, 130, 269-281.
- Colas, I.; Macaulay, M.; Higgins, J.D.; Phillips, D.; Barakate, A.; Posch, M.; Armstrong, S.J.; Franklin, F.C.H.; Halpin, C.; Waugh, R.; Ramsay, L. (2016) A spontaneous mutation in MutL-Homolog 3 (HvMLH3) affects synapsis and crossover resolution in the barley desynaptic mutant des10., New Phytologist, 212, 693-707.
- Travis, A.J.; Norton, G.J.; Datta, S.; Sarma, R.; Dasgupta, T.; Savio, F.L.; Macaulay, M.; Hedley, P.E.; McNally, K.L.; Sumon, M.H.; Islam, M.R.; Price, A.H. (2015) Assessing the genetic diversity of rice originating from Bangladesh, Assam and West Bengal., Rice, 8, Article No. 35.
- Phillips, D.; Jenkins, G.; Macaulay, M.; Nibau, C.; Wnetrzak, J.; Fallding, D.; Colas, I.; Oakey, H.; Waugh, R.; Ramsay, L. (2015) The effect of temperature on the male and female recombination landscape of barley., New Phytologist, 208, 421-429.
- Forsberg, N.E.G.; Russell, J.; Macaulay, M.; Leino, M.W.; Hagenblad, J. (2015) Farmers without borders - genetic structuring in century old barley (Hordeum vulgare)., Heredity, 114, 195-206.
- Bertholdsson, N.O.; Holefors, A.; Macaulay, M.; Crespo-Herrera, L.A. (2015) QTL for chlorophyll fluorescence of barley plants grown at low oxygen concentration in hydroponics to simulate waterlogging., Euphytica, 201, 357-365.
- Yelina, N.E.; Choi, K.; Chelysheva, L.; Macaulay, M.; de Snoo, B.; Wijnker, E.; Miller, N.; Drouaud, J.; Grelon, M.; Copenhaver, G.P.; Mezard, C.; Kelly, K.A.; Henderson, I.R. (2012) Epigenetic remodeling of meiotic crossover frequency in arabidopsis thaliana DNA methyltransferase mutants., PLoS Genetics, 8, Article No. e1002844.
- Houston, K.; Druka, A.; Bonar, N.; Macaulay, M.; Lundqvist, U.; Franckowiak, J.D.; Morgante, M.; Stein, N.; Waugh, R. (2012) Analysis of the barley bract suppression gene Trd1., Theoretical and Applied Genetics, 125, 33-45.
- Looseley, M.; Newton, A.C.; Atkins, S.D.; Fitt, B.D.L.; Fraaije, B.A.; Thomas, W.T.B.; Keith, R.; Macaulay, M.; Lynott, J.S.; Harrap, D. (2012) Genetic basis of control of Rhynchosporium secalis infection and symptom expression in barley., Euphytica, 184, 47-56.
- Hofinger, B.J.; Russell, J.R.; Bass, C.G.; Baldwin, T.; dos Reis, M.; Hedley, P.E.; Li, Y.; Macaulay, M.; Waugh, R.; Hammond-Kosack, K.E.; Kanyuka, K. (2011) An exceptionally high nucleotide and haplotype diversity and a signature of positive selection for the eIF4E resistance gene in barley are revealed by allele mining and phylogenetic analyses of natural populations., Molecular Ecology, 20, 3653-3668.
- Ramsay, L.; Comadran, J.; Druka, A.; Marshall, D.F.; Thomas, W.T.B.; Macaulay, M.; MacKenzie, K.; Simpson, C.G.; Fuller, J.; Bonar, N.; Hayes, P.M.; Lundqvist, U.; Franckowiak, J.D.; Close, T.J.; Muehlbauer, G.; Waugh, R. (2011) INTERMEDIUM-C, a modifier of lateral spikelet fertility in barley, is an ortholog of the maize domestication gene TEOSINTE BRANCHED 1., Nature Genetics, 43, 169-172.
- Cockram, J.; White, J.; Zuluaga, D.; Smith, D.; Comadran, J.; Macaulay, M.; Luo, Z.W.; Kearsey, M.J.; Werner, P.; Harrap, D.; Tapsell, C.; Liu, H.; Hedley, P.E.; Stein, N.; Schulte, D.; Steuernagel, B.; Marshall, D.F.; Thomas, W.T.B.; Ramsay, L.; Mackay, I.; Balding, D.J.; Waugh, R.; O'Sullivan, D.M. (2010) Genome-wide association mapping to candidate polymorphism resolution in the unsequenced barley genome., Proceedings of the National Academy of Sciences of the United States of America (PNAS), 107, 21611-21616.
- Druka, A.; Franckowiak, J.D.; Lundqvist, U.; Bonar, N.; Alexander, J.; Guzy-Wrobelska, J.; Ramsay, L.; Druka, I.; Grant, I.; Macaulay, M.; Vendramin, V.; Shahinnia, F.; Radovic, S.; Houston, K.; Harrap, D.; Cardle, L.; Marshall, D.F.; Morgante, M.; Stein, N.; Waugh, R. (2010) Exploiting induced variation to dissect quantitative traits in barley., Biochemical Society Transactions, 38, 683-688.
- Rae, S.J.; Macaulay, M.; Ramsay, L.; Leigh, F.; Matthews, D.; O'Sullivan, D.M.; Donini, P.; Morris, P.C.; Powell, W.; Marshall, D.F.; Waugh, R.; Thomas, W.T.B. (2007) Molecular barley breeding., Euphytica, 158, 295-303.
- Ramsay, L.; Russell, J.R.; Macaulay, M.; Booth, A.; Thomas, W.T.B. (2004) Variation shown by molecular markers in barley: Genomic and genetic constraints., Aspects of Applied Biology, 72, 147-154.
- Macaulay, M.; Russell, J.R.; Ramsay, L.; Marshall, D.F.; Powell, W.; Waugh, R.; Thomas, W.T.B. (2004) Lessons from barley recommended lists., Annual Report of the Scottish Crop Research Institute for 2003/2004, pp144-145.
- Ramsay, L.; Caldwell, K.; Russell, J.R.; Macaulay, M.; Thomas, W.T.B.; Powell, W.; Waugh, R. (2003) Linkage disequilibrium in barley., Annual Report of the Scottish Crop Research Institute for 2002/2003, p114.
- Macaulay, M.; Ramsay, L.; Powell, W.; Waugh, R. (2001) A representative, highly informative 'genotyping set' of barley SSRs., Theoretical and Applied Genetics, 102, 801-809.
- Ramsay, L.; Macaulay, M.; degli Ivanissevich, S.D.; MacLean, K.; Cardle, L.; Fuller, J.D.; Edwards, K.J.; Tuvesson, S.; Morgante, M.; Massari, A.; Maestri, E.; Marmiroli, N.; Sjakste, T.; Ganal, M.; Powell, W.; Waugh, R. (2000) A simple sequence repeat-based linkage map of barley., Genetics, 156, 1997-2005.
- Cardle, L.; Ramsay, L.; Milbourne, D.; Macaulay, M.; Marshall, D.F.; Waugh, R. (2000) Computational and experimental characterization of physically clustered simple sequence repeats in plants., Genetics, 156, 847-854.
- Cardle, L.; Macaulay, M.; Marshall, D.F.; Milbourne, D.; Ramsay, L.; Waugh, R. (2000) SSR frequency and occurrence in plant genomes., Annual Report of the Scottish Crop Research Institute for 1999/2000, pp108-110.
- Thomas, W.T.B.; Newton, A.C.; Wilson, A.; Booth, A.; Macaulay, M.; Keith, R. (2000) Development of recombinant chromosome substitution lines - a barley resource., Annual Report of the Scottish Crop Research Institute for 1999/2000, pp99-100.
- Ramsay, L.; Macaulay, M.; Cardle, L.; Morgante, M.; degli Ivanissevich, S.; Maestri, E.; Powell, W.; Waugh, R. (1999) Intimate association of microsatellite repeats with retrotransposons and other dispersed repetitive elements in barley., Plant Journal, 17, 415-425.
- Ellis, R.P.; Macaulay, M.; Hackett, C.A.; Forster, B.P. (1998) The genetic control of ear emergence time in barley, Hordeum vulgare L.: Linkage between Vrn1, Bmy1, Wsp3 and a quantitative trait for time of ear emergence on chromosome 4H., In: Naqvi, S.S.M. (ed.). New Genetical Approaches to Crop Improvement. Atomic Energy Research Centre, Tando Jam 70060, Pakistan, pp619-630.
- Russell, J.R.; Fuller, J.D.; Macaulay, M.; Hatz, B.G.; Jahoor, A.; Powell, W.; Waugh, R. (1997) Direct comparison of levels of genetic variation among barley accessions detected by RFLPs, AFLPs, SSRs and RAPDs., Theoretical and Applied Genetics, 95, 714-722.
- Russell, J.R.; Fuller, J.D.; Young, G.; Thomas, W.T.B.; Taramino, G.; Macaulay, M.; Waugh, R.; Powell, W. (1997) Discriminating between barley genotypes and microsatellite markers., Genome, 40, 442-450.
- Pakniyat, H.; Handley, L.L.; Thomas, W.T.B.; Connolly, T.; Macaulay, M.; Caligari, P.D.S.; Forster, B.P. (1997) Comparison of shoot dry weight, Na+ content and delta C-13 values of ari-e and other semi-dwarf barley mutants under salt-stress., Euphytica, 94, 7-14.
- Thomas, W.T.B.; Russell, J.R.; Bonar, N.; Booth, A.; Fuller, J.D.; Lawrence, P.; Macaulay, M.; Ramsay, L.; Waugh, R.; Powell, W. (1997) Simple sequence repeats SSRs and QTL mapping in barley crosses.., In: H. Buerstmayer & P. Ruckenbauer (eds.). Application of Marker Aided Selection in Cereal Breeding Programs. Eucarpia Section Cereals Meeting. Tulln, Austria, 28-29.
- Macaulay, M.; Provan, J.; Russell, J.R.; Fuller, J.D.; Dewar, H.; Milbourne, D.; Meyer, R.; Collins, A.; White, G.; Powell, W.; Waugh, R. (1996) Isolation, characterisation and use of SSRs as genetic markers., Annual Report of the Scottish Crop Research Institute for 1995, pp54-55.
- Colas, I.; Barakate, A.; Macaulay, M.; Schreiber, M.; Stephens, J.; Vivera, S.; Halpin, C.; Waugh, R.; Ramsay, L. (2019) Desynaptic5 carries a spontaneous semi-dominant mutation affecting Disrupted Meiotic cDNA 1 (DMC1) in barley., Journal of Experimental Botany, 70, 2683-2698.
- Looseley, M.E.; Griffe, L.L.; Büttner, B.; Wright, K.M.; Middlefell-Williams, J.; Bull, H.; Shaw, P.D.; Macaulay, M.; Booth, A.; Schweizer, G.; Russell, J.R.; Waugh, R.; Thomas, W.T.B.; Avrova, A. (2018) Resistance to Rhynchosporium commune in a collection of European spring barley germplasm., Theoretical and Applied Genetics, 131, 2513-2528.
- Castro, A.J.; Cuesta-Marcos, A.; Hayes, P.M.; Locatelli, A.; Macaulay, M.; Mastandrea, N.; Silveira, M.; Thomas, W.T.B.; Viega, L. (2017) The completely additive effects of two barley phenology-related genes (eps2S and sdw1) are explained by specific effects at different periods within the crop growth cycle., Plant Breeding, 136, 663-670.
- Bayer, M.; Ganal, M.; Hedley, P.E.; Macaulay, M.; Plieske, J.; Ramsay, L.; Rapazote-Flores, P.; Russell, J.; Shaw, P.; Thomas, W.; Waugh, R. (2017) Development and evaluation of a barley 50k iSelect SNP array., Frontiers in Plant Science, 8, Article No. 1792.
- Liller, C.B.; Walla, A.; Boer, M.P.; Hedley, P.; Macaulay, M.; Effgen, S.; von Korff, M.; van Esse, G.W.; Koornneef, M. (2017) Fine mapping of a major QTL for awn length in barley using a multiparent mapping population., Theoretical and Applied Genetics, 130, 269-281.
- Colas, I.; Macaulay, M.; Higgins, J.D.; Phillips, D.; Barakate, A.; Posch, M.; Armstrong, S.J.; Franklin, F.C.H.; Halpin, C.; Waugh, R.; Ramsay, L. (2016) A spontaneous mutation in MutL-Homolog 3 (HvMLH3) affects synapsis and crossover resolution in the barley desynaptic mutant des10., New Phytologist, 212, 693-707.
- Travis, A.J.; Norton, G.J.; Datta, S.; Sarma, R.; Dasgupta, T.; Savio, F.L.; Macaulay, M.; Hedley, P.E.; McNally, K.L.; Sumon, M.H.; Islam, M.R.; Price, A.H. (2015) Assessing the genetic diversity of rice originating from Bangladesh, Assam and West Bengal., Rice, 8, Article No. 35.
- Phillips, D.; Jenkins, G.; Macaulay, M.; Nibau, C.; Wnetrzak, J.; Fallding, D.; Colas, I.; Oakey, H.; Waugh, R.; Ramsay, L. (2015) The effect of temperature on the male and female recombination landscape of barley., New Phytologist, 208, 421-429.
- Forsberg, N.E.G.; Russell, J.; Macaulay, M.; Leino, M.W.; Hagenblad, J. (2015) Farmers without borders - genetic structuring in century old barley (Hordeum vulgare)., Heredity, 114, 195-206.
- Bertholdsson, N.O.; Holefors, A.; Macaulay, M.; Crespo-Herrera, L.A. (2015) QTL for chlorophyll fluorescence of barley plants grown at low oxygen concentration in hydroponics to simulate waterlogging., Euphytica, 201, 357-365.
- Yelina, N.E.; Choi, K.; Chelysheva, L.; Macaulay, M.; de Snoo, B.; Wijnker, E.; Miller, N.; Drouaud, J.; Grelon, M.; Copenhaver, G.P.; Mezard, C.; Kelly, K.A.; Henderson, I.R. (2012) Epigenetic remodeling of meiotic crossover frequency in arabidopsis thaliana DNA methyltransferase mutants., PLoS Genetics, 8, Article No. e1002844.
- Houston, K.; Druka, A.; Bonar, N.; Macaulay, M.; Lundqvist, U.; Franckowiak, J.D.; Morgante, M.; Stein, N.; Waugh, R. (2012) Analysis of the barley bract suppression gene Trd1., Theoretical and Applied Genetics, 125, 33-45.
- Looseley, M.; Newton, A.C.; Atkins, S.D.; Fitt, B.D.L.; Fraaije, B.A.; Thomas, W.T.B.; Keith, R.; Macaulay, M.; Lynott, J.S.; Harrap, D. (2012) Genetic basis of control of Rhynchosporium secalis infection and symptom expression in barley., Euphytica, 184, 47-56.
- Hofinger, B.J.; Russell, J.R.; Bass, C.G.; Baldwin, T.; dos Reis, M.; Hedley, P.E.; Li, Y.; Macaulay, M.; Waugh, R.; Hammond-Kosack, K.E.; Kanyuka, K. (2011) An exceptionally high nucleotide and haplotype diversity and a signature of positive selection for the eIF4E resistance gene in barley are revealed by allele mining and phylogenetic analyses of natural populations., Molecular Ecology, 20, 3653-3668.
- Ramsay, L.; Comadran, J.; Druka, A.; Marshall, D.F.; Thomas, W.T.B.; Macaulay, M.; MacKenzie, K.; Simpson, C.G.; Fuller, J.; Bonar, N.; Hayes, P.M.; Lundqvist, U.; Franckowiak, J.D.; Close, T.J.; Muehlbauer, G.; Waugh, R. (2011) INTERMEDIUM-C, a modifier of lateral spikelet fertility in barley, is an ortholog of the maize domestication gene TEOSINTE BRANCHED 1., Nature Genetics, 43, 169-172.
- Cockram, J.; White, J.; Zuluaga, D.; Smith, D.; Comadran, J.; Macaulay, M.; Luo, Z.W.; Kearsey, M.J.; Werner, P.; Harrap, D.; Tapsell, C.; Liu, H.; Hedley, P.E.; Stein, N.; Schulte, D.; Steuernagel, B.; Marshall, D.F.; Thomas, W.T.B.; Ramsay, L.; Mackay, I.; Balding, D.J.; Waugh, R.; O'Sullivan, D.M. (2010) Genome-wide association mapping to candidate polymorphism resolution in the unsequenced barley genome., Proceedings of the National Academy of Sciences of the United States of America (PNAS), 107, 21611-21616.
- Druka, A.; Franckowiak, J.D.; Lundqvist, U.; Bonar, N.; Alexander, J.; Guzy-Wrobelska, J.; Ramsay, L.; Druka, I.; Grant, I.; Macaulay, M.; Vendramin, V.; Shahinnia, F.; Radovic, S.; Houston, K.; Harrap, D.; Cardle, L.; Marshall, D.F.; Morgante, M.; Stein, N.; Waugh, R. (2010) Exploiting induced variation to dissect quantitative traits in barley., Biochemical Society Transactions, 38, 683-688.
- Rae, S.J.; Macaulay, M.; Ramsay, L.; Leigh, F.; Matthews, D.; O'Sullivan, D.M.; Donini, P.; Morris, P.C.; Powell, W.; Marshall, D.F.; Waugh, R.; Thomas, W.T.B. (2007) Molecular barley breeding., Euphytica, 158, 295-303.
- Ramsay, L.; Russell, J.R.; Macaulay, M.; Booth, A.; Thomas, W.T.B. (2004) Variation shown by molecular markers in barley: Genomic and genetic constraints., Aspects of Applied Biology, 72, 147-154.
- Macaulay, M.; Ramsay, L.; Powell, W.; Waugh, R. (2001) A representative, highly informative 'genotyping set' of barley SSRs., Theoretical and Applied Genetics, 102, 801-809.
- Ramsay, L.; Macaulay, M.; degli Ivanissevich, S.D.; MacLean, K.; Cardle, L.; Fuller, J.D.; Edwards, K.J.; Tuvesson, S.; Morgante, M.; Massari, A.; Maestri, E.; Marmiroli, N.; Sjakste, T.; Ganal, M.; Powell, W.; Waugh, R. (2000) A simple sequence repeat-based linkage map of barley., Genetics, 156, 1997-2005.
- Cardle, L.; Ramsay, L.; Milbourne, D.; Macaulay, M.; Marshall, D.F.; Waugh, R. (2000) Computational and experimental characterization of physically clustered simple sequence repeats in plants., Genetics, 156, 847-854.
- Ramsay, L.; Macaulay, M.; Cardle, L.; Morgante, M.; degli Ivanissevich, S.; Maestri, E.; Powell, W.; Waugh, R. (1999) Intimate association of microsatellite repeats with retrotransposons and other dispersed repetitive elements in barley., Plant Journal, 17, 415-425.
- Russell, J.R.; Fuller, J.D.; Macaulay, M.; Hatz, B.G.; Jahoor, A.; Powell, W.; Waugh, R. (1997) Direct comparison of levels of genetic variation among barley accessions detected by RFLPs, AFLPs, SSRs and RAPDs., Theoretical and Applied Genetics, 95, 714-722.
- Russell, J.R.; Fuller, J.D.; Young, G.; Thomas, W.T.B.; Taramino, G.; Macaulay, M.; Waugh, R.; Powell, W. (1997) Discriminating between barley genotypes and microsatellite markers., Genome, 40, 442-450.
- Pakniyat, H.; Handley, L.L.; Thomas, W.T.B.; Connolly, T.; Macaulay, M.; Caligari, P.D.S.; Forster, B.P. (1997) Comparison of shoot dry weight, Na+ content and delta C-13 values of ari-e and other semi-dwarf barley mutants under salt-stress., Euphytica, 94, 7-14.
- Ellis, R.P.; Macaulay, M.; Hackett, C.A.; Forster, B.P. (1998) The genetic control of ear emergence time in barley, Hordeum vulgare L.: Linkage between Vrn1, Bmy1, Wsp3 and a quantitative trait for time of ear emergence on chromosome 4H., In: Naqvi, S.S.M. (ed.). New Genetical Approaches to Crop Improvement. Atomic Energy Research Centre, Tando Jam 70060, Pakistan, pp619-630.
- Thomas, W.T.B.; Russell, J.R.; Bonar, N.; Booth, A.; Fuller, J.D.; Lawrence, P.; Macaulay, M.; Ramsay, L.; Waugh, R.; Powell, W. (1997) Simple sequence repeats SSRs and QTL mapping in barley crosses.., In: H. Buerstmayer & P. Ruckenbauer (eds.). Application of Marker Aided Selection in Cereal Breeding Programs. Eucarpia Section Cereals Meeting. Tulln, Austria, 28-29.
- Macaulay, M.; Russell, J.R.; Ramsay, L.; Marshall, D.F.; Powell, W.; Waugh, R.; Thomas, W.T.B. (2004) Lessons from barley recommended lists., Annual Report of the Scottish Crop Research Institute for 2003/2004, pp144-145.
- Ramsay, L.; Caldwell, K.; Russell, J.R.; Macaulay, M.; Thomas, W.T.B.; Powell, W.; Waugh, R. (2003) Linkage disequilibrium in barley., Annual Report of the Scottish Crop Research Institute for 2002/2003, p114.
- Cardle, L.; Macaulay, M.; Marshall, D.F.; Milbourne, D.; Ramsay, L.; Waugh, R. (2000) SSR frequency and occurrence in plant genomes., Annual Report of the Scottish Crop Research Institute for 1999/2000, pp108-110.
- Thomas, W.T.B.; Newton, A.C.; Wilson, A.; Booth, A.; Macaulay, M.; Keith, R. (2000) Development of recombinant chromosome substitution lines - a barley resource., Annual Report of the Scottish Crop Research Institute for 1999/2000, pp99-100.
- Macaulay, M.; Provan, J.; Russell, J.R.; Fuller, J.D.; Dewar, H.; Milbourne, D.; Meyer, R.; Collins, A.; White, G.; Powell, W.; Waugh, R. (1996) Isolation, characterisation and use of SSRs as genetic markers., Annual Report of the Scottish Crop Research Institute for 1995, pp54-55.
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