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Micha Bayer

Staff picture: Micha Bayer
Information and Computational Sciences
Information and Computational Sciences
Bioinformatics Specialist
micha.bayer@hutton.ac.uk
+44 (0)344 928 5428 (*)

The James Hutton Institute
Invergowrie
Dundee DD2 5DA
Scotland UK

 

I am a bioinformatics specialist with a focus on second and third generation sequence analysis and 14 years of experience in barley genomics, variomics and transcriptomics. My post was created at the start of the next generation sequencing era and I am one of the early pioneers of applying these technologies to barley. I was part of the consortia for the barley genome projects in 2012 and 2017 and a co-author on several high-impact publications revolving around the analysis of genetic variation in barley. I was also the lead bioinformatician for the last two barley genotyping platforms, the Illumina iSelect 9k and 50k genotyping chips. I have been involved in the two barley reference transcriptome projects, leading to high-quality barley reference transcript datasets (BART1 and BART2). Other projects I have been involved in include the identification of Rhynchosporium resistance genes, candidate genes for diastatic power and diagnostic markers for epiheterodendrin (EPH).

  • Bioinformatics Specialist, Information and Computational Sciences group
  • Specialises in analysis of Next Generation Sequencing data from crop plants
  • Main focus: genomics and variomics (in particular in barley)

Current research interests

Nature cover 2017Over the years I have been involved in a large variety of projects across most of our crop plant species, but most of my research currently relates to barley. My particular interest is in barley variomics and genomics. I have been actively involved in the last two barley genome projects, and also in the development of the last two barley high throughout genotyping platforms. I have an active interest in the quality issues Next Generation Sequencing data and its analysis suffer from, and as part of this I recently supervised a PhD project looking at the generation of false positive SNPs during variant calling. Due to the high demand for bioinformatics analysis skills, I now also spend a substantial amount of my time teaching, supervising and mentoring both staff and students. I have been involved in delivering bioinformatics training courses both internationally and locally, at the James Hutton Institute and University of Dundee.

  • BBSRC European Partnership Award "The exploitation and sharing of barley resources" 2021-2025 (Co-I)
  • BBSRC Responsive mode "The Generation Gap - Mechanisms of maternal control on grain" 2021-2024 (Co-PI)
  • BBSRC Responsive mode "R-EVOLVE" 2021-2025 (subcontract)
  • BBSRC Responsive mode "Developing nutrient-enriched cereal grains with large embryos" 2019-2022 (named researcher)
  • BBSRC BBR "A Reference Transcript Dataset for improved analysis of RNA-seq data from barley" 2018-2020 (subcontract)
  • ERA-CAPS network "BARley yield associated Network (BARN)" 2018-2021 (subcontract)
  • BBSRC Responsive mode "Mechanisms underlying variation in barley hull adhesion" 2018-2021 (subcontract)
  • Innovate UK "EPH Elimination from Malting Barley for Scotch Whisky Production" 2017-2018 (Co-I)
  • TSB/BBSRC AgriTech Catalyst "Breeding Targets for Durable Resistance to Rhynchosporium  (DRRUM)" 2016-2019 (Co-I)
  • HGCA/AHDB "A genome wide analysis of key genes controlling diastatic power activity in UK barley" 2015-2017 (Co-I)
  • BBSRC Crop Improvement Research Club (CIRC) "Fungal effectors as activators of novel resistances in cereals." 2012-2016 (Researcher Co-I)
  • BBSRC Responsive mode "The diversity and evolution of the gene component of barley peri-centromeric heterochromatin" 2011-2014 (named researcher)

Past research

  • May2008 - present: Bioinformatics Specialist, The James Hutton Institute (prev. SCRI)
  • March 2006 - May2008: Software Developer, Scottish Bioinformatics Research Network (SBRN), SCRI
  • September 2003 – February 2006: Grid Developer, National e-Science Centre (Glasgow Hub), University of Glasgow
  • September 2002 - September 2003: MSc Information Technology, Glasgow University
  • July 1998 – August 2002: Postdoctoral Researcher, Royal Botanic Garden Edinburgh (species identification of algae by computer vision)
  • February 1998 – June 1998: Postdoctoral Research Fellow, Gatty Marine Laboratory, St Andrews University (development of microsatellites for population genetics in marine invertebrates)
  • June 1994 – January 1998: PhD Marine Biology, St Andrews University (phenotypic plasticity in marine bryozoans)

Bibliography

  • Bayer, M.; Morris, J.; Booth, C.; Booth, A.; Uzrek, N.; Russell, J.R.; Waugh, R.; Hedley, P.E. (2019) Exome capture for variant discovery and analysis in barley., In: Harwood, W.A. (ed.). Barley: Methods and Protocols. Methods in Molecular Biology, Humana Press, New York, Volume 1900, Chapter 18, pp283-310.
  • Simpson, C.G.; Barrero, R.A.; Bayer, M.; Flavell, A.; Rapazote-Flores, P.; Bellgard, M.I.; Hedley, P.E.; Zhang, R.; Waugh, R. (2018) The expressed portion of the barley genome., In: Stein, N. & Muehlbauer, G. (eds.). The Barley Genome, Compendium of Plant Genomes. Springer, Cham, Switzerland, Chapter 7, 789-107.
  • Twardziok, S.; Gundlach, H.; Hedley, P.E.; Bayer, M.; Platzer, M.; Groth, M.; Waugh, R.; Spannagl, M. (2018) Gene prediction in the barley genome., In: Stein, N. & Muehlbauer, G. (eds.). The Barley Genome, Compendium of Plant Genomes. Springer, Cham, Switzerland, Chapter 6, 73-88.
  • Milne, I.; Bayer, M.; Stephen, G.; Cardle, L.; Marshall, D. (2016) Tablet: visualizing next-generation sequence assemblies and mappings., In: Edwards, D. (ed.). Plant Bioinformatics: Methods and Protocols, Methods in Molecular Biology. Springer Science+Business Media, New York, 14, pp253-268.

  • Milne, I.; Shaw, P.; Milne, L.; Bayer, M.; Stephen, G.; Marshall, D.F. (2010) Visualising genetic diversity., Annual Report of the Scottish Crop Research Institute for 2009, pp21-22.

  • Chen, X.; Bayer, M.; Harrower, B.; Stevens, L.; Chapman, S.; Gilroy, E.; van Weymers, P.; Jupe, F.; Witek, K.; Jones, J.; Birch, P.; Bryan, G.; Hein, I. (2014) Using the potato genome to map and clone durable resistance genes more rapidly., Crop Protection in Northern Britain, Environmental Management and Crop Protection, West Park Conference Centre, Dundee, 25-26 February 2014.
  • Avrova, A.; Gamble, L.; Griffe, L.; Ruiz, O.; Munsterkotter, M.; Bayer, M.; Looseley, M.E.; Knogge, W.; Newton, A.C.; Birch, P.R.; Hammond-Kosack K.E.; Kanyuka, K. (2014) From Rhynchosporium commune genome sequence to barley resistance., Crop Protection in Northern Britain, Environmental Management and Crop Protection, West Park Conference Centre, Dundee, 25-26 February 2014.
  • Gamble, L.; Munsterkotter, M.; Bayer, M.; Knogge, W.; Newton, A.C.; Birch, P.R.J.; Avrova, A. (2014) On the path of discovery: Rhynchosporium commune effectors activating scald resistance in barley., Crop Protection in Northern Britain, Environmental Management and Crop Protection, West Park Conference Centre, Dundee, 25-26 February 2014.
  • Shaw, P.; Milne, I.; Cardle, L.; Waugh, R.; Thomas, W.T.B.; Ramsay, L.; Comadran, J.; Stephen G.; Bayer, M.; Graham, M.; Kennedy J.; Oakey, H.; Marshall, D.F. (2012) Visualizing genetic transmission patterns in plant pedigrees., Plant and Animal Genome XX, San Diego, California, 14-18 January 2012.
  • Bayer, M.; Liu, H.; Marshall, D.F.; Russell, J.; Hedley, P.E.; Milne, I.; Stephen G.; Waugh, R.; (2011) A GBS data processing pipeline for barley., StatSeq Meeting on Genotyping by Sequencing. Wageningen, Netherlands, 3-4 November 2011 (Talk).
  • Bayer, M.M.; Russell, J.R.; Milne, L.; Hedley, P.E.; Marshall, D.F. (2010) SNP discovery in barley Illumina data using Mosaik, GigaBayes and Tablet., 2nd Workshop of COST StatSeq Action (TD0801), Ghent, Belgium, 20-21 May 2010.
  • Shaw, P.; Cardle, L.; Milne, I.; Waugh, R.; Flavell, A.; Thomas, W.T.B.; Grzebyta, J.; Bayer, M.; Marshall, D.F. (2009) Germinate 2: A platform for Illumina SNP genotyping experiments and high volume phenotypic data., Plant & Animal Genome XVII, San Diego, California, 10-14 January 2009.

Printed from /staff/micha-bayer on 29/11/22 12:22:37 PM

The James Hutton Research Institute is the result of the merger in April 2011 of MLURI and SCRI. This merger formed a new powerhouse for research into food, land use, and climate change.