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Robert Hancock

Staff picture: Robert Hancock
Cell and Molecular Sciences
Cell and Molecular Sciences
Plant Biochemist
rob.hancock@hutton.ac.uk
+44(0)1382 568779

The James Hutton Institute
Invergowrie
Dundee DD2 5DA
Scotland UK

 

Robert Hancock is a senior biochemist and plant physiologist with 25 years post-qualification experience. His primary interests are concerned with the biochemical determinants and impact of biotic and abiotic stress on crop quality and how crop management and management systems can influence yield and quality. He works in soft fruits, potatoes and cereals where he has extensive industry links across the production and retail chain. His laboratory uses a range of physiological, biochemical, analytical and molecular techniques to understand the impact of stress on crop quality at a systems level. This research is supported by links with bioinformaticians working within Biomathematics and Statistics Scotland (BioSS), co-located at the James Hutton Institute.  Fundamental work is complemented by more applied aspects of research which are facilitated through close interactions with colleagues working in the area of molecular breeding as well as extensive interactions and joint research projects with industrial partners.

Current research interests

My current research interests focus on the impact of plant genotype, the biotic and the abiotic environment on crop quality with particular focus on the role of reactive oxygen signalling and the cellular redox environment in modulating plant responses to environmental cues. I conduct a mixture of both fundamental and applied research adopting a physiological, biochemical and increasingly molecular approach. Primary crops of interest are potatoes and soft fruit.

The laboratory currently hosts three PhD students. Two of these research projects aim to understand the interaction between genetics and environment in the accumulation of phytochemicals associated with quality in soft fruit (blackcurrants and blueberries) and a further project is examining plant responses to aphids.

In blueberry we aim to understand the relationship between fruit chemistry and sensory attributes in collaboration with colleagues at the University of Strathclyde. In addition, we aim to understand the interplay between crop genetics and growing environment with respect to the accumulation of compounds providing potential health benefits to consumers (vitamin C, polyphenolic antioxidants). Our analytical and biochemical work feeds into a genetic map being produced by colleagues to allow the rapid breeding of blueberry cultivars suitable for production of fruit meeting UK consumer expectations.

A similar approach is being applied to understanding the accumulation of a range of phytochemicals in blackcurrant fruit. Here we aim to characterise genes associated with the accumulation of specific phytochemicals by developing a blackcurrant microarray to allow analysis of global gene expression throughout the course of fruit ripening. Fruit phytochemistry changes dramatically over the course of ripening and by combining phytochemical analysis with gene expression studies we aim to identify genes contributing to phytochemical accumulation. This will feed into the Hutton blackcurrant breeding programme providing candidate genes for cultivar improvement.

Microarray technologies, in combination with metabolome analysis has allowed us to characterise the response of the model plant Arabidopsis to aphid infestation. In collaboration with colleagues at the University of Leeds, we have demonstrated the divergence of local and systemic responses and identified cellular redox processes as key determinants of the plant response. This has been further verified by analysis of mutants that have low vitamin C levels and hence a more oxidised cellular redox environment. Furthermore, we have been able to demonstrate that redox processes are also key in the response of crops (potato) to aphid infestation.

The laboratory is also currently funded by the Scottish Government to develop an understanding of potato to heat stress in order to breed heat resistant cultivars. Our focus is on understanding the impact of high temperatures on carbon partitioning within the plant and the role of redox processes on carbon assimilation, transport and metabolism.

  • Innovate UK Strawberry molecular breeding 10015546 2022-2025 (£298,987) (PI)
  • BBSRC GCRF ZIRON Pulse BB/T008865/1 2020 – 2023 (£1M) (Co-I)

Past research

My initial work at the Institute took a biochemical and physiological approach to understanding the accumulation of vitamin C in blackcurrant fruit and potato tubers. We were able to demonstrate that in addition to biosynthesis within the fruit or tuber, vitamin C was transported long distance from leaves via the phloem. Additional work involved the development of engineered yeast strains capable of vitamin C biosynthesis. I have also worked on key plant developmental programmes including bud dormancy, potato dormancy and potato tuberisation. Applied work included a Scottish Enterprise funded programme developing methods for the extension of shelf-life in minimally processed (fresh-cut) fruit and vegetables.

Bibliography

  • Hancock, R.D.; Petridis, A.; McDougall, G.J. (2018) Raspberry fruit chemistry in relation to fruit quality and human nutrition., In: Graham, J. & Brennan, R. (eds.). Raspberry. Springer Nature, Cham, Switzerland, Chapter 7, pp89-119
  • Hancock, R. (2017) Oxidative stress., In: Thomas, B., Murray, B.G. & Murphy, D.J. (eds.). Encyclopedia of Applied Plant Sciences, Volume 1, Waltham, MA: Academic Press, pp. 27-35.
  • Hancock, R.D.; Stewart, D. (2010) Enhancing the nutritional quality of fruit juices: advanced technologies for juice extraction and pasteurization., In: Bagchi, D., Lau, F.C. & Ghosh, D. (eds.). Biotechnology In Functional Foods and Nutraceuticals. CRC Press, Boca Raton, FLA, USA, 463-482.

  • Kerchev, P.I.; Saraswat, V.; Hedley, P.E.; Morris, J.; Fenton, B.; Foyer, C.H.; Hancock, R.D. (2011) Understanding local and systemic responses to aphid infestation as a tool towards breeding aphid resistant crops., Annual Report of the Scottish Crop Research Institute for 2010, pp40-42.
  • Ross, H.A.; Morris, W.L.; Ducreux, L.J.M.; Hancock, R.D.; Verrall, S.R.; Morris, J.A.; Stewart, D.; Hedley, P.E.; McDougall, G.J.; Taylor, M.A. (2011) The role of pectin methyl esterase in determining potato tuber textural quality., Annual Report of the Scottish Crop Research Institute for 2010, pp32-33.
  • Walker, P.G.; Pont, S.D.A.; Marquis, N.; Hancock, R.D. (2008) Mechanism of vitamin C accumulation in blackcurrant fruit., Annual Report of the Scottish Crop Research Institute for 2007, pp34-35.
  • Mazzitelli, L.; Hancock, R.D.; Haupt, S.; McNicol, J.W.; Viola, R.; Brennan, R.M.; Hedley, P.E.; Taylor, M.A. (2006) Understanding dormancy release in raspberry buds., Annual Report of the Scottish Crop Research Institute for 2006, pp32-33.
  • Pont, S.D.A.; Walker, P.G.; Lamond, S.; Fenton, B.; Hancock, R.D. (2005) Aphid reproduction is modulated by phloem ascorbic acid - novel targets for pest control?., Annual Report of the Scottish Crop Research Institute for 2004/2005, pp34-35.
  • Hancock, R.D.; McRae, D.; Haupt, S.; Viola, R. (2003) Biosynthesis of vitamin C in plant phloem., Annual Report of the Scottish Crop Research Institute for 2002/2003, pp110-111.
  • Hancock, R.D.; Viola, R. (2002) Ascorbic acid biosynthesis in higher plants and micro-organisms., Annual Report of the Scottish Crop Research Institute for 2001/2002, pp135-139.

  • Miller, T.W.; Jarret, D.A.M.; Brennan, R.M.; Hancock, R.D. (2016) Does primocane management affect raspberry fruit yield or anthocyanin content?, Acta Horticulturae, 1133, 363-369.
  • Zhang, K.; Rasool, B.; Pastok, D.; Morris, J.; Verrall, S.R.; Hedley, P.E.; Hancock, R.D.; Foyer, C.H. (2016) The redox state of the apoplast influences acclimation to changing irradiance in tobacco (Nicotiana tobaccum)., Enhancing Photosynthesis in Crop Plants: Targets for Improvement, Discussion Meeting, Royal Society, London, 10-11 October 2016.
  • Shepherd, L.V.T.; Pont, S.D.A.; Bryan, G.J.; Dale, M.F.B.; Hancock, R.D.; Hedley, P.E.; Morris, J.A.; Verrall, S.R.; Hackett, C.A.; McNicol, J.W.; Davies, H.V. (2013) Acrylamide forming potential of potato: predictive tools and genetic interactions., Aspects of Applied Biology, 116, 53-60.
  • Hancock, R.D.; Morris, W.L.; Ducreux, L.J.M.; Morris, J.; Usman, M.; Verrall, S.R.; Hedley, P.E.; Taylor, M.A. (2013) High temperature inhibition of potato tuberisation is associated with altered redox status and associated transcript profiles., 11th International PCA Conference - Reactive Oxygen and Nitrogen Species in Plants, Warsaw, 17-19 July 2013.
  • Hancock, R.D.; Jarret, D.; Morris, J.; Jorgensen L.; Verrall, S.R.; Hedley, P.E.; Brennan, R.M. (2013) Developing a transcriptomic and metabolomic map of blackcurrant fruit development for the identification of key genes associated with quality traits., UK PlantSci 2013, University of Dundee, Dundee, 16-17 April 2013.
  • Jarret, D.; Rowbottom, S.; Morris, J.; Jorgensen, L.; Verrall, S.R.; Hedley, P.E.; Brennan, R.M.; Hancock, R.D. (2013) Comparative transcriptome and metabolome analysis of developing blackcurrant seed provides an insight into pathway-specific gene-metabolite co-expression., Aspects of Applied Biology 119, 2013 Fruit and Roots: A celebration and forward look, East Malling Research, 6-7 November 2013.
  • McCallum, S.; Cullen, D.W.; Hedley, P.; Simpson, C.; Hancock, R.D.; Milne, L.; Hackett, C.A.; Graham J. (2013) Control of fruit quality traits in red raspberry, a review from James Hutton Institute., Fruits and Roots: A Celebration and Forward look, East Malling Research, Kent, 6-7 November 2013.
  • Messner C.; Paterson, A.; McCallum, S.; Graham, J.; Hancock, R.D. (2012) Genetic and environmental drivers of fruit composition in relation to sensory quality in blueberry., 1st Agriscience Chemical Biology Postgraduate Symposium, London, 1-2 November 2012.
  • Messner C.; Paterson, A.; McCallum, S.; Graham, J.; Hancock, R.D. (2012) Genetic and environmental drivers of fruit composition in relation to sensory quality in blueberry., SEB Annual Main Meeting 2012, Salzburg, Austria, 29 June - 2 July 2012.
  • Iannetta, P.P.M.; Escobar, N.M.; Ross, H.A.; Souleyre, E.; Hancock, R.D.; Fairlie, J.; Davies, H.V. (2000) Tricarboxylic enzymes in ripening strawberry fruits., Proceedings of the Fourth International Strawberry Symposium, Tampere, Finland, 9-14 July 2000. ISHS Acta Horticulturae (2002), 567, 731-733.

  • Mateos, B.; Jennings, N.; Hancock, R.; Graham, J. (2022) Identifying main factors determining dormancy release in raspberry, conference
  • Morris, W.L.; Ducreux, L.J.M.; Craita Bita, E.; Trapero-Mozos, A.; Hancock, R.D.; Taylor, M.A. (2017) Climate proofing potato: Understanding the response to heat and drought., Potatoes in Practice, Balruddery Farm, Dundee, 10 August, 2017. (Poster)
  • Jia, Y.; Burbidge, C.; Sweetman, C.; Hancock, R.; Soole, K.; Bruning, J.; Ford, C. (2016) Enzymes of tartaric acid synthesis. II: Vv2kGR - a member of the hydroxypyruvate reductase family with activity against 2-keto Lgulonate., Xth International Symposium on Grapevine Physiology and Biotechnology, Verona, Italy, 13-18 June 2016.
  • Smith, D.; Geoghegan, I.; Hancock, R.D. (2015) Influence of substrate on sugar-acid balance in coir grown strawberry cv.Capri., 8th North American Strawberry Symposium, Ventura, California, 3-6 February 2015.
  • Hancock, R.D.; Morris, W.L.; Ducreux, L.J.M.; Morris, J.; Usman, M.; Verrall, S.R.; Hedley, P.E.; Taylor, M.A. (2013) High temperature inhibition of potato tuberisation is associated with altered redox status and associated transcript pro¿les., UK Plant Science Conference, West Park Centre, Dundee, 16-17 April 2013. (Poster)
  • Morris, W.L.; Ducreux, L.; Usman, M.; Hedley, P.; Verrall, S.; Zhang, R.; Morris, J.; Hancock, R.D. (2013) A physiological, biochemical and transcriptomic approach to understanding the response of potato to elevated temperature., UK Plant Science Conference, West Park Centre, Dundee, 16-17 April 2013. (Poster)
  • Comadira, G.; Hancock, R.D.; Krupinska, K.; Foyer, C.H. (2013) The effect of Whirly transcription factor (HvWhy1) in the regulation of photosynthesis and leaf transcript and metabolite profiles in barley under nitrogen deficiency and nitrogen-replete conditions., UK PlantSci 2013, Dundee, 16-17 April 2013 (Abstract).
  • Jarret, D.; Hancock, R.D.; Hedley, P.E.; Flavell, A.J.; Brennan, R.M. (2011) Towards an understanding of genetic control of processing quality traits in blackcurrant., Xth International Rubus and Ribes Symposiumn Zlatibor, Serbia, 22-26 June 2011. (Poster)
  • Kerchev, P.I.; Fenton, B.; Foyer, C.H.; Hancock, R.D. (2011) A role for redox components in the local and systmeic respones of Arabidopsis thaliana to aphid infestation., 10th International Conference on Reactive Oxygen and Nitrogen Species in Plants, Budapest, Hungary, 5-8 July 2011 (Poster).
  • Pont, S.D.A.; Ponte, A.; Shepherd, L.V.T.; Davies, H.V.; Hancock, R.D. (2011) Towards reduced acrylamide potato products: Analysis of precuros accumulation pathways using 13C-labelling in conjunction with GC/MS., PlantEngine Plant Metabolic Engineering for High Value Products, Murcia, Spain,17-18 November 2011.
  • McCallum, S.; Graham, J.; Hackett, C.A.; Hancock, R.D.; McKenzie, B.M.; Hallett, P.D.; Jorgensen, L.; Gordon, S.; Woodhead, M.; Brennan, R.M.; Rowland, L.J.; Bassil, N.; Olmstead, J.; Buck, E.; Hancock, J. (2010) Investigating the suitability of blueberry germplasm for UK production and developing tools for long-term breeding., Proceedings of the North American Blueberry Research and Extension Workers Conference (NABREW), Kalamazoo, Michigan, USA, 25-28 July 2010. (Poster)
  • Birch, A.N.E.; Shepherd, T.; Hancock, R.D.; Goszcz, K. (2010) Sugar sensing in inducible plant defence against multiple pest types., Scottish Plant Biology Meeting, University of Dundee, 22 April 2010.
  • Kerchev, P.; Foyer, C.H.; Fenton, B.; Hancock, R.D. (2009) Investigating roles for reactive oxygen in plant-aphid interactions., Plant ROS 2009: Society for Free Radical Research International Plant Oxygen Group Meeting on Reactive Oxygen and Nitrogen Species. Helsinki, Finland, 8-10 July 2009. (Poster).
  • Birch, A.N.E.; Shepherd, T.; Hancock, R.D.; Goszcz, K. (2009) Understanding sugar sensing in induced plant defences and stress tolerance., International Society of Chemical Ecology, Neuchatel, Switzerland, 23-25 August 2009.
  • Kerchev, P.; Foyer, C.H.; Fenton, B.; Hancock, R.D. (2009) Reactive oxygen and antioxidants modulate the interaction between Myzus persicae (Sulzer) and plant hosts., 8th International Symposium on Aphids, Catania, Italy, 8-12 June 2009 (Poster).
  • Mazzitelli, L.; Pont, S.D.A.; Walker, P.G.; Haupt, S.; Tilsner, J.; Taylor, M.A.; Hedley, P.E.; McNicol, J.W.; Hancock, R.D.; Viola, R. (2006) Molecular characterisation of dormancy phase transition in raspberry (Rubus idaeus L.) buds., Scottish Plant Molecular Biology Group Meeting. St Andrews, 13 January 2006 (Poster).
  • Mazzitelli, L.; Hein, I.; Hedley, P.E.; Haupt, S.; Tilsner, J.; Williamson, S.; Morris, J.; Pont, S.D.A.; Hancock, R.D.; Brennan, R.M.; Viola, R.; McNicol, J.W.; Russell, J.R.; Taylor, M.A. (2006) Microarray-based gene expression studies of dormancy phase transition in raspberry (Rubus idaeus L.) buds., 3rd International Rosaceae Conference. Napier, New Zealand, 19-22 March 2006 (Poster).
  • Hancock, R.D. (2006) Thermal treatments for enhancing shelf life of minimally processed foods., Excellence in Food Manufacture 2006, London, 1 November 2006 (Poster).
  • Hancock, R.D.; Walker, P.G.; Pont, S.D.A.; Smirnoff, N.; Viola, R. (2006) Ascorbic acid conjugates in phloem exudates of Cucurbitaceae., Proceedings of the 15th Congress of the Federation of European Societies of Plant Biology, Lyon, France, 17-21 July 2006 (Poster).
  • Walker, P.G.; Pont, S.D.A.; Viola, R.; Hancock, R.D. (2006) L-ascorbic acid accumulation in fruit of blackcurrant (Ribes nigrum L.)., Proceedings of the 15th Congress of the Federation of European Societies of Plant Biology, Lyon, France, 17-21 July 2006 (Poster).

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The James Hutton Research Institute is the result of the merger in April 2011 of MLURI and SCRI. This merger formed a new powerhouse for research into food, land use, and climate change.