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Csaba Hornyik

Staff picture: Csaba Hornyik
Cell and Molecular Sciences
Cell and Molecular Sciences
Senior Research Scientist
Csaba.Hornyik@hutton.ac.uk
+44 (0)344 928 5428 ext 8970

The James Hutton Institute
Invergowrie
Dundee DD2 5DA
Scotland UK

 

Current research interests

As part of the Potato Research Group I aim to investigate how potato tubers are formed:

  • analysis of genetic pathways which can regulate tuber formation
  • exploration of the micro RNA (miRNA) transcriptome in potato and investigation the role of miRNAs in tuberization
  • analysis of important Quantitative Trait Loci (QTL) and find candidate genes regulating these agricultural traits.

Past research

I worked in the laboratory of Dr Gordon G. Simpson on characterisation of flowering time (2007-2010, SCRI/University of Dundee, Invergowrie, Dundee, Scotland, UK) through:

  • analysis and characterization of RNA binding proteins that control flowering time
  • analysis of mechanisms by which ambient temperature influences flowering time.

During my Marie Curie Intra-European Fellowship I was involved in the following projects in the laboratory of Dr Christophe Lacomme (2005-2007, SCRI, Invergowrie, Dundee, Scotland, UK).

  • Cross-talk of different defence pathways during pathogenesis in cereals (EU FP6, Marie Curie Intra-European Fellowship MEIF-CT-2005-025076).
  • Analysis of RNA-directed RNA polymerase 1 and 6 in barley during fungal and viral infection (collaboration with David Leader, SCRI; Merete Albrechtsen, University of Aarhus, Tjele, Denmark).
  •  5’splice site mediated inhibition of gene expression (collaboration with Krzysztof Wypijewski, SCRI).

I was involved in the following projects during my PhD in the lab of Dr Jozsef Burgyan (1998-2005, ABC, Godollo, Hungary).

  • Molecular analysis of symptom attenuation of defective interfering RNAs in Tombusvirus infected plants and its connection to RNA silencing.
  • Improvement in detection of micro RNAs (miRNA) and investigation their expression pattern in Nicotiana benthamiana plants.
  • Molecular characterization of RNA silencing suppressor protein (p19) of Tombusviruses which was the first well characterised silencing suppressor protein of plant viruses.
  • Analysis of Tombusvirus induced infection.

Previous Publications:

  • Hornyik C, Havelda Z, Burgyan J. (2006) Identification of sequence elements of tombusvirus-associated defective interfering RNAs required for symptom modulation. Arch Virol. Mar; 151 (3):625-33. Epub 2005 Nov 17.
  • Csaba Hornyik*, Zoltán Havelda*, Anna Válóczi and József Burgyán (2005) Defective interfering RNA hinders the activity of tombusvirus encoded post-transcriptional gene silencing suppressor. J Virol. Jan; 79(1):450-7. (* These authors contributed equally to this work.)
  • Anna Válóczi, Csaba Hornyik, Nóra Varga, József Burgyán, Sakari Kauppinen, Zoltán Havelda (2004) Sensitive and specific detection of microRNAs by Northern blot analysis using LNA-modified oligonucleotide probes. Nucleic Acids Res. Dec 14; 32(22):e175.
  • Z. Havelda, C. Hornyik, A. Crescenzi and J. Burgyán (2003) In situ characterization of Cymbidium ringspot tombusvirus infection induced post-transcriptional gene silencing in Nicotiana benthamiana. J Virol. May; 77(10):6082-6.
  • Silhavy D, Molnar A, Lucioli A, Szittya G, Hornyik C, Tavazza M, Burgyan J. (2002) A viral protein suppresses RNA silencing and binds silencing-generated, 21- to 25-nucleotide double-stranded RNAs. EMBO J, 21(12):3070-3080.
  • Szittya G, Molnar A, Silhavy D, Hornyik C, Burgyan J. (2002) Short defective interfering RNAs of tombusviruses are not targeted but trigger post-transcriptional gene silencing against their helper virus. Plant Cell, 14 (2):359-72.
  • J. Burgyán, Cs. Hornyik, Gy. Szittya, D. Silhavy, and Gy. Bisztray. (2000). The ORF1 products of tombusviruses play a crucial role in lethal necrosis of virus-infected Plants. J Virol. 74: 10873-10881.

Qualifications

  • PhD (Biology, Plant Biotechnology), Budapest, Hungary, 2005.
  • Diploma in Chemistry and Biology, Budapest, Hungary, 1997.

External Activities

  • Editor, Open Life Sciences (Plant Sciences, Plant Genetics and Biotechnology).
  • Member of Biochemical Society and The European Plant Science Organisation (EPSO).

Bibliography


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The James Hutton Research Institute is the result of the merger in April 2011 of MLURI and SCRI. This merger formed a new powerhouse for research into food, land use, and climate change.