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J. William (Will) Allwood
For over 18 years Will has worked as a researcher in the field of metabolomics and metabolite profiling. He is interested in the study and development of chromatography - linked - mass spectrometry (LC and GC) for a range of applications in the fields of plant-physiology, pathology and insect interactions, as well as natural product discovery. Will was a core researcher within the two teams who were first recognised for applying metabolomics approaches to the study of plant disease and insect interactions. Will has previously run and provided metabolic profiling services within the Universities of Manchester and Birmingham across many plant science, microbiological and human clinical, studies. Will is currently responsible for the LC-MS metabolomics services at James Hutton Institute – Dundee, where he serves as both an LC-MS technologist and a research scientist. Will also serves as the current deputy leader of the Plant Biochemistry and Food Quality (PBFQ) programme within the Environmental and Biochemical Sciences group.
Measures of esteem:
- MDPI Metabolites (Section editor, Plant metabolomics: 2020-present)
- Springer Metabolomics journal (Editorial Board Member 2011-present)
- Springer Metabolomics journal (Guest editor for themed collection on Food and nutrition, 2017-2018)
- The Scottish Metabolomics Network (Board Member 2017-present)
- Local organiser for the International Metabolomics Society conference, Manchester 2007.
- Local organiser for The Metabolic Profiling Forum – MetaboMeeting, International Conference, Manchester 2012.
- Local organiser for The Scottish Metabolomics Network – annual meeting, Dundee, 1-2nd November 2018.
- Reviewer for the following SCI journals: Analytical Chemistry, Journal of Proteome Research, Journal of Natural Products, Rapid Communications in Mass Spectrometry, Analytical Biochemistry, Analyst, Analytical and Bioanalytical Chemistry, Journal of Chromatography A, Journal of Chromatography B, Metabolomics, Metabolites, Frontiers in metabolomics, Plant Physiology, Plant Cell, Plant Journal, Journal of Experimental Botany, Phytochemistry, Physiologia Plantarum, Journal of Agricultural and Food Chemistry, Phytochemical Analysis, Environmental and Experimental Botany, Plant Methods, Frontiers in plant biology.
Bibliography
- Abukhabta, S,; Ghawi, S.K.; Karatzas, K.A.; Charalampopoulos, D.; McDougall, G.; Allwood, J.W.; Verrall, S.; Lavery, S.; Latimer, C.; Pourshahidi, K.; Lawther, R.; O’Connor, G.; Rowland, I.; Gil, C.I.R. (In press) Sulforaphane-enriched extracts from super broccoli soup exert anti-microbial activity against gut pathogens and innovative cooking methods increase in vivo intestinal delivery of sulforphane., European Journal of Nutrition.
- Allwood, J.W.; Evans, H.; Austin, C.; McDougall, G.J. (2020) Extraction, enrichment, and LC-MSn-based characterization of phlorotannins and related phenolics from the brown seaweed, Ascophyllum nodosum., Marine Drugs, 18, Article No. 448.
- Okamoto, H.; Ducreux, L.J.M.; Allwood, J.W.; Hedley, P.E.; Wright, A.; Gururajan, V.; Terry, M.J.; Taylor, M.A. (2020) Light regulation of chlorophyll and glycoalkaloid biosynthesis during tuber greening of potato S. tuberosum., Frontiers in Plant Science, 11, Article No. 753.
- Moing, A.; Allwood, J.W.; Aharoni, A.; Baker, J.; Beale, M.H.; Ben-Dor, S.; Biais, B.; Brigante, F.; Burger, Y.; Deborde, C.; Erban, A.; Faigenboim, A.; Gur, A.; Goodacre, R.; Hansen, T.H.; Jacob, D.; Katzir, N.; Kopka, J.; Lewinsohn, E.; Maucourt, M.; Meir, S.; Miller, S.; Mumm, R.; Oren, E.; Paris, H.S.; Rogachev, I.; Rolin, D.; Saar, U.; Schjoerring, J.K.; Tadmor, Y.; Tzuri, G.; de Vos, R.C.H.; Ward, J.L.; Yeselson, E.; Hall, R.D.; Schaffer, A.A. (2020) Comparative metabolomics and molecular phylogenetics of melon (Cucumis melo, Cucurbitaceae) biodiversity., Metabolites, 10,
- Mori, K.; Beauvoit, B.P.; Benoît, B.; Maxime, C.; Allwood, J.W.; Deborde, C.; Maucourt, M.; Goodacre, R.; Cabasson, C.; Moing, A.; Rolin, D.; Gibon, Y. (2019) Central metabolism Is tuned to the availability of oxygen in developing melon fruit., Frontiers in Plant Science, 10, Article No.594.
- Hayward, N.J.; McDougall, G.J.; Farag, S.; Allwood, J.W.; Austin, C.; Campbell, F.; Horgan, G.; Ranawana, V. (2019) Cinnamon shows antidiabetic properties that are species-specific: effects on enzyme activity inhibition and starch digestion., Plant Foods for Human Nutrition, 74, 544-552.
- Haugeneder, A.; Trinkl, J.; Hartl, K.; Hoffmann, T.; Allwood, J.W.; Schwab, W. (2019) Correction to: answering biological questions by analysis of the strawberry metabolome (vol 14, 145, 2018)., Metabolomics, 15, p40.
- Kallscheuer, N.; Menezes, R.; Foito, A.; Silva, M.H.; Braga, A.; Dekker, W.; Sevillano, D.M.; Rosado-Ramos, R.; Jardim, C.; Oliveira, J.; Ferreira, P.; Rocha, I.; Silva, A.R.; Sousa, M.; Allwood, J.W.; Bott, M.; Faria, N.; Stewart, D.; Ottens, M.; Naesby, M.; Santos, C.N.; Marienhagen, J. (2019) Identification and microbial production of the raspberry phenol Salidroside that is active against Huntington’s Disease., Plant Physiology, 179, 969-985.
- Allwood, J.W.; Xu, Y.; Martinez-Martin, P.; Palau, R.; Cowan, A.; Goodacre, R.; Marshall, A.; Stewart, D.; Howarth, C. (2019) Rapid UHPLC-MS metabolite profiling and phenotypic assays reveal genotypic impacts of nitrogen supplementation in oats., Metabolomics, 15, Article No. 42.
- Allwood, J.W.; Woznicki, T.L.; Xu, Y.; Foito, A.; Aaby, K.; Sungurtas, J.; Freitag, S.; Goodacre, R.; Stewart, D.; Rember, S.F.; Heide, O.M.; Sønsteby, A. (2019) Application of HPLC-PDA-MS metabolite profiling to investigate the effect of growth temperature and day length on blackcurrant fruit., Metabolomics, 15, Article No. 12.
- Solopova, A.; van Tilburg, A.Y.; Foito, A.; Allwood, J.W.; Stewart, D.; Kulakauskas, S.; Kuipers, O.P. (2019) Engineering Lactococcus lactis for the production of unusual anthocyanins using tea as substrate., Metabolic Engineering, 54, 160-169.
- Jarret, D.A.; Morris, J.; Cullen, D.W.; Gordon, S.L.; Verrall, S.R.; Milne, L.; Hedley, P.E.; Allwood, J.W.; Brennan, R.M.; Hancock, R.D. (2018) A transcript and metabolite atlas of blackcurrant fruit development highlights hormonal regulation and reveals the role of key transcription factors., Frontiers in Plant Science, 9, Article No. 1235.
- AlRabiah, H.; Allwood, J.W.; Correa, E.; Xu, Y.; Goodacre, R. (2018) pH plays a role in the mode of action of trimethoprim on Escherichia coli., PLoS ONE, 13, Article No. e0200272.
- Logie, L.; Lees, Z.; Allwood, J.W.; McDougall, G.J.; Beall, C.; Rena, G. (2018) Regulation of hepatic glucose production and AMPK by AICAR but not by metformin depends on drug uptake through the equilibrative nucleoside transporter 1 (ENT1)., Diabetes, Obesity and Metabolism, 20, 2748-2758.
- Haugeneder, A.; Trinkl, J.; Härtl, K.; Hoffmann, T.; Allwood, J.W.; Schwab, W. (2018) Answering biological questions by analysis of the strawberry metabolome., Metabolomics, 14, Article No. 145.
- Ternan, N.G.; Moore, N.D.; Smyth, D.; McDougall, G.J.; Allwood, J.W.; Verrall, S.; Gill, C.I.R.; Dooley, J.S.G.; McMullan, G. (2018) Increased sporulation underpins adaptation of Clostridium difficile strain 630 to a biologically-relevant faecal environment, with implications for pathogenicity., Scientific Reports, 8, Article No. 16691.
- Freitag, S.; Verrall, S.R.; Pont, S.D.A.; McRae, D.; Sungartas, J.A.; Palau, R.; Hawes, C.; Alexander, C.J.; Allwood, J.W.; Foito, A.; Stewart, D.; Shepherd, L.V.T. (2018) Impact of conventional and integrated management systems on the water-soluble vitamin content in potatoes, field beans and cereals., Journal of Agricultural and Food Chemistry, 66, 831-841.
- Austin, C.; Stewart, D.; Allwood, J.W.; McDougall, G.J. (2018) Extracts from the edible seaweed, Ascophyllum nodosum, inhibit lipase activity in vitro: contributions of phenolic and polysaccharide components., Food and Function, 9, 502-510.
- O’Reilly, M.W.; Kempegowda, P.; Walsh, M.; Taylor, A.E.; Manolopoulos, K.N.; Allwood, J.W.; Semple, R.K.; Hebenstreit, D.; Dunn, W.B.; Tomlinson, J.W.; Arlt, W. (2017) AKR1C3-mediated adipose androgen generation drives lipotoxicity in women with polycystic ovary syndrome., The Journal of Clinical Endocrinology and Metabolism, 102, 3327-3339.
- McDougall, G.J.; Allwood, J.W.; Pereira-Caro, G.; Brown, E.M.; Latimer, C.; Dobson, G.; Stewart, D.; Ternan, N.G.; Lawther, R.; O'Connor, G.; Rowland, I.; Crozier, A.; Gill, C.I.R. (2017) The composition of potentially bioactive triterpenoid glycosides in red raspberry is influenced by tissue, extraction procedure and genotype., Food and Function, 8, 3469-3479.
- McDougall, G.J.; Allwood, J.W.; Pereira-Caro, G.; Brown, E.M.; Verrall, S.; Stewart, D.; Latimer, C.; McMullan, G.; Lawther, R.; O'Connor, G.; Rowland, I.; Crozier, A.; Gill, C.I.R. (2017) Novel colon-available triterpenoids identified in raspberry fruits exhibit antigenotoxic activities in vitro., Molecular Nutrition and Food Research, 61, Article No. 1600327.
- Pérez-Schindler, J.; Kanhere, A.; Edwards, L.; Allwood, J.W.; Dunn, W.B.; Schenk, S.; Philp, A. (2017) Exercise and high-fat feeding remodel transcript-metabolite interactive networks in mouse skeletal muscle., Scientific Reports, 7, Article No. 13485.
- Harvie, M.N.; Sims, A.H.; Pegington, M.; Spence, K.; Mitchell, A.; Vaughan, A.A.; Allwood, J.W.; Xu, Y.; Rattray, N.J.W.; Goodacre, R.; Evans, D.G.R.; Mitchell, E.; McMullen, D.; Clarke, R.B.; Howell, A. (2016) Intermittent energy restriction induces changes in breast gene expression and systemic metabolism., Breast Cancer Research, 18, Article 57.
- Di Guida, R.; Engel, J.; Allwood, J.W.; Weber, R.J.M.; Jones, M.R.; Sommer, U.; Viant, M.R.; Dunn, W.B. (2016) Non-targeted UHPLC-MS metabolomic data processing methods: a comparative investigation of normalisation, missing value imputation, transformation and scaling., Metabolomics, 12, 1-14.
- Dunn, W.B.; Allwood, J.W.; Van Mieghem, T.; Morris, R.K.; Mackie, F.L.; Fox, C.E.; Kilby, M.D. (2016) Carbohydrate and fatty acid perturbations in the amniotic fluid of the recipient twin of pregnancies complicated by twin-twin transfusion syndrome in relation to treatment and fetal cardiovascular risk., Placenta, 44, 6-12.
- McDougall, G.J.; Allwood, J.W.; Pereira-Caro, G.; Brown, E.M.; Ternan, N.; Verrall, S.; Stewart, D.; Lawther, R.; O'Connor, G.; Rowland, I.; Crozier, A.; Gill, C.I.R. (2016) Non-targeted LC-MSn profiling of compounds in ileal fluids that decrease after raspberry intake identifies consistent alterations in bile acid composition., Journal of Natural Products, 79, 2606-2615.
- Roberto, B.S.; Macedo, G.A.; Macedo, J.A.; Martins, I.M.; Nakajima, V.M.; Allwood, J.W.; Stewart, D.; McDougall, G.J. (2016) Immobilized tannase treatment alters polyphenolic composition in teas and their potential anti-obesity and hypoglycemic activities in vitro., Food and Function, 7, 3920-3932.
- Bajhaiya, A.K.; Dean, A.P.; Driver, T.; Trivedi, D.K.; Rattray, N.J.W.; Allwood, J.W.; Goodacre, R.; Pittman, J.K. (2016) High-throughput metabolic screening of microalgae genetic variation in response to nutrient limitation., Metabolomics, 12, Article No. 9.
- Ludwig, C.; Williams, D.S.; Bartlett, D.B.; Essex, S.J.; McNee, G.; Allwood, J.W.; Jewell, E.; Barkhuisen, A.; Parry, H.; Anandram, S.; Nicolson, P.; Gardener, C.; Seymour, F.; Basu, S.; Dunn, W.B.; Moss, P.A.H.; Pratt, G.; Tennant, D.A. (2015) Alterations in bone marrow metabolism are an early and consistent feature during the development of MGUS and multiple myeloma., Blood Cancer Journal, 5, Article e359.
- Madu, U.L.; Ogundeji, A.O.; Mochochoko, B.M.; Pohl, C.H.; Albertyn, J.; Swart, C.W.; Allwood, J.W.; Southam, A.D.; Dunn, W.B.; May, R.C.; Sebolai, O.M. (2015) Cryptococcal 3-hydroxy fatty acids protect cells against amoebal phagocytosis., Frontiers in Microbiology, 6, Article 1351.
- Driver, T.; Bajhaiya, A.K.; Allwood, J.W.; Goodacre, R.; Pittman, J.K.; Dean, A.P. (2015) Metabolic responses of eukaryotic microalgae to environmental stress limit the ability of FT-IR spectroscopy for species identification., Algal Research - Biomass Biofuels and Bioproducts, 11, 148-155.
- Allwood, J.W.; Evans, H.; Austin, C.; McDougall, G.J. (2020) Extraction, enrichment, and LC-MSn-based characterization of phlorotannins and related phenolics from the brown seaweed, Ascophyllum nodosum., Marine Drugs, 18, Article No. 448.
- Okamoto, H.; Ducreux, L.J.M.; Allwood, J.W.; Hedley, P.E.; Wright, A.; Gururajan, V.; Terry, M.J.; Taylor, M.A. (2020) Light regulation of chlorophyll and glycoalkaloid biosynthesis during tuber greening of potato S. tuberosum., Frontiers in Plant Science, 11, Article No. 753.
- Moing, A.; Allwood, J.W.; Aharoni, A.; Baker, J.; Beale, M.H.; Ben-Dor, S.; Biais, B.; Brigante, F.; Burger, Y.; Deborde, C.; Erban, A.; Faigenboim, A.; Gur, A.; Goodacre, R.; Hansen, T.H.; Jacob, D.; Katzir, N.; Kopka, J.; Lewinsohn, E.; Maucourt, M.; Meir, S.; Miller, S.; Mumm, R.; Oren, E.; Paris, H.S.; Rogachev, I.; Rolin, D.; Saar, U.; Schjoerring, J.K.; Tadmor, Y.; Tzuri, G.; de Vos, R.C.H.; Ward, J.L.; Yeselson, E.; Hall, R.D.; Schaffer, A.A. (2020) Comparative metabolomics and molecular phylogenetics of melon (Cucumis melo, Cucurbitaceae) biodiversity., Metabolites, 10,
- Mori, K.; Beauvoit, B.P.; Benoît, B.; Maxime, C.; Allwood, J.W.; Deborde, C.; Maucourt, M.; Goodacre, R.; Cabasson, C.; Moing, A.; Rolin, D.; Gibon, Y. (2019) Central metabolism Is tuned to the availability of oxygen in developing melon fruit., Frontiers in Plant Science, 10, Article No.594.
- Hayward, N.J.; McDougall, G.J.; Farag, S.; Allwood, J.W.; Austin, C.; Campbell, F.; Horgan, G.; Ranawana, V. (2019) Cinnamon shows antidiabetic properties that are species-specific: effects on enzyme activity inhibition and starch digestion., Plant Foods for Human Nutrition, 74, 544-552.
- Haugeneder, A.; Trinkl, J.; Hartl, K.; Hoffmann, T.; Allwood, J.W.; Schwab, W. (2019) Correction to: answering biological questions by analysis of the strawberry metabolome (vol 14, 145, 2018)., Metabolomics, 15, p40.
- Kallscheuer, N.; Menezes, R.; Foito, A.; Silva, M.H.; Braga, A.; Dekker, W.; Sevillano, D.M.; Rosado-Ramos, R.; Jardim, C.; Oliveira, J.; Ferreira, P.; Rocha, I.; Silva, A.R.; Sousa, M.; Allwood, J.W.; Bott, M.; Faria, N.; Stewart, D.; Ottens, M.; Naesby, M.; Santos, C.N.; Marienhagen, J. (2019) Identification and microbial production of the raspberry phenol Salidroside that is active against Huntington’s Disease., Plant Physiology, 179, 969-985.
- Allwood, J.W.; Xu, Y.; Martinez-Martin, P.; Palau, R.; Cowan, A.; Goodacre, R.; Marshall, A.; Stewart, D.; Howarth, C. (2019) Rapid UHPLC-MS metabolite profiling and phenotypic assays reveal genotypic impacts of nitrogen supplementation in oats., Metabolomics, 15, Article No. 42.
- Allwood, J.W.; Woznicki, T.L.; Xu, Y.; Foito, A.; Aaby, K.; Sungurtas, J.; Freitag, S.; Goodacre, R.; Stewart, D.; Rember, S.F.; Heide, O.M.; Sønsteby, A. (2019) Application of HPLC-PDA-MS metabolite profiling to investigate the effect of growth temperature and day length on blackcurrant fruit., Metabolomics, 15, Article No. 12.
- Solopova, A.; van Tilburg, A.Y.; Foito, A.; Allwood, J.W.; Stewart, D.; Kulakauskas, S.; Kuipers, O.P. (2019) Engineering Lactococcus lactis for the production of unusual anthocyanins using tea as substrate., Metabolic Engineering, 54, 160-169.
- Jarret, D.A.; Morris, J.; Cullen, D.W.; Gordon, S.L.; Verrall, S.R.; Milne, L.; Hedley, P.E.; Allwood, J.W.; Brennan, R.M.; Hancock, R.D. (2018) A transcript and metabolite atlas of blackcurrant fruit development highlights hormonal regulation and reveals the role of key transcription factors., Frontiers in Plant Science, 9, Article No. 1235.
- AlRabiah, H.; Allwood, J.W.; Correa, E.; Xu, Y.; Goodacre, R. (2018) pH plays a role in the mode of action of trimethoprim on Escherichia coli., PLoS ONE, 13, Article No. e0200272.
- Logie, L.; Lees, Z.; Allwood, J.W.; McDougall, G.J.; Beall, C.; Rena, G. (2018) Regulation of hepatic glucose production and AMPK by AICAR but not by metformin depends on drug uptake through the equilibrative nucleoside transporter 1 (ENT1)., Diabetes, Obesity and Metabolism, 20, 2748-2758.
- Haugeneder, A.; Trinkl, J.; Härtl, K.; Hoffmann, T.; Allwood, J.W.; Schwab, W. (2018) Answering biological questions by analysis of the strawberry metabolome., Metabolomics, 14, Article No. 145.
- Ternan, N.G.; Moore, N.D.; Smyth, D.; McDougall, G.J.; Allwood, J.W.; Verrall, S.; Gill, C.I.R.; Dooley, J.S.G.; McMullan, G. (2018) Increased sporulation underpins adaptation of Clostridium difficile strain 630 to a biologically-relevant faecal environment, with implications for pathogenicity., Scientific Reports, 8, Article No. 16691.
- Freitag, S.; Verrall, S.R.; Pont, S.D.A.; McRae, D.; Sungartas, J.A.; Palau, R.; Hawes, C.; Alexander, C.J.; Allwood, J.W.; Foito, A.; Stewart, D.; Shepherd, L.V.T. (2018) Impact of conventional and integrated management systems on the water-soluble vitamin content in potatoes, field beans and cereals., Journal of Agricultural and Food Chemistry, 66, 831-841.
- Austin, C.; Stewart, D.; Allwood, J.W.; McDougall, G.J. (2018) Extracts from the edible seaweed, Ascophyllum nodosum, inhibit lipase activity in vitro: contributions of phenolic and polysaccharide components., Food and Function, 9, 502-510.
- O’Reilly, M.W.; Kempegowda, P.; Walsh, M.; Taylor, A.E.; Manolopoulos, K.N.; Allwood, J.W.; Semple, R.K.; Hebenstreit, D.; Dunn, W.B.; Tomlinson, J.W.; Arlt, W. (2017) AKR1C3-mediated adipose androgen generation drives lipotoxicity in women with polycystic ovary syndrome., The Journal of Clinical Endocrinology and Metabolism, 102, 3327-3339.
- McDougall, G.J.; Allwood, J.W.; Pereira-Caro, G.; Brown, E.M.; Latimer, C.; Dobson, G.; Stewart, D.; Ternan, N.G.; Lawther, R.; O'Connor, G.; Rowland, I.; Crozier, A.; Gill, C.I.R. (2017) The composition of potentially bioactive triterpenoid glycosides in red raspberry is influenced by tissue, extraction procedure and genotype., Food and Function, 8, 3469-3479.
- McDougall, G.J.; Allwood, J.W.; Pereira-Caro, G.; Brown, E.M.; Verrall, S.; Stewart, D.; Latimer, C.; McMullan, G.; Lawther, R.; O'Connor, G.; Rowland, I.; Crozier, A.; Gill, C.I.R. (2017) Novel colon-available triterpenoids identified in raspberry fruits exhibit antigenotoxic activities in vitro., Molecular Nutrition and Food Research, 61, Article No. 1600327.
- Pérez-Schindler, J.; Kanhere, A.; Edwards, L.; Allwood, J.W.; Dunn, W.B.; Schenk, S.; Philp, A. (2017) Exercise and high-fat feeding remodel transcript-metabolite interactive networks in mouse skeletal muscle., Scientific Reports, 7, Article No. 13485.
- Harvie, M.N.; Sims, A.H.; Pegington, M.; Spence, K.; Mitchell, A.; Vaughan, A.A.; Allwood, J.W.; Xu, Y.; Rattray, N.J.W.; Goodacre, R.; Evans, D.G.R.; Mitchell, E.; McMullen, D.; Clarke, R.B.; Howell, A. (2016) Intermittent energy restriction induces changes in breast gene expression and systemic metabolism., Breast Cancer Research, 18, Article 57.
- Di Guida, R.; Engel, J.; Allwood, J.W.; Weber, R.J.M.; Jones, M.R.; Sommer, U.; Viant, M.R.; Dunn, W.B. (2016) Non-targeted UHPLC-MS metabolomic data processing methods: a comparative investigation of normalisation, missing value imputation, transformation and scaling., Metabolomics, 12, 1-14.
- Dunn, W.B.; Allwood, J.W.; Van Mieghem, T.; Morris, R.K.; Mackie, F.L.; Fox, C.E.; Kilby, M.D. (2016) Carbohydrate and fatty acid perturbations in the amniotic fluid of the recipient twin of pregnancies complicated by twin-twin transfusion syndrome in relation to treatment and fetal cardiovascular risk., Placenta, 44, 6-12.
- McDougall, G.J.; Allwood, J.W.; Pereira-Caro, G.; Brown, E.M.; Ternan, N.; Verrall, S.; Stewart, D.; Lawther, R.; O'Connor, G.; Rowland, I.; Crozier, A.; Gill, C.I.R. (2016) Non-targeted LC-MSn profiling of compounds in ileal fluids that decrease after raspberry intake identifies consistent alterations in bile acid composition., Journal of Natural Products, 79, 2606-2615.
- Roberto, B.S.; Macedo, G.A.; Macedo, J.A.; Martins, I.M.; Nakajima, V.M.; Allwood, J.W.; Stewart, D.; McDougall, G.J. (2016) Immobilized tannase treatment alters polyphenolic composition in teas and their potential anti-obesity and hypoglycemic activities in vitro., Food and Function, 7, 3920-3932.
- Bajhaiya, A.K.; Dean, A.P.; Driver, T.; Trivedi, D.K.; Rattray, N.J.W.; Allwood, J.W.; Goodacre, R.; Pittman, J.K. (2016) High-throughput metabolic screening of microalgae genetic variation in response to nutrient limitation., Metabolomics, 12, Article No. 9.
- Ludwig, C.; Williams, D.S.; Bartlett, D.B.; Essex, S.J.; McNee, G.; Allwood, J.W.; Jewell, E.; Barkhuisen, A.; Parry, H.; Anandram, S.; Nicolson, P.; Gardener, C.; Seymour, F.; Basu, S.; Dunn, W.B.; Moss, P.A.H.; Pratt, G.; Tennant, D.A. (2015) Alterations in bone marrow metabolism are an early and consistent feature during the development of MGUS and multiple myeloma., Blood Cancer Journal, 5, Article e359.
- Madu, U.L.; Ogundeji, A.O.; Mochochoko, B.M.; Pohl, C.H.; Albertyn, J.; Swart, C.W.; Allwood, J.W.; Southam, A.D.; Dunn, W.B.; May, R.C.; Sebolai, O.M. (2015) Cryptococcal 3-hydroxy fatty acids protect cells against amoebal phagocytosis., Frontiers in Microbiology, 6, Article 1351.
- Driver, T.; Bajhaiya, A.K.; Allwood, J.W.; Goodacre, R.; Pittman, J.K.; Dean, A.P. (2015) Metabolic responses of eukaryotic microalgae to environmental stress limit the ability of FT-IR spectroscopy for species identification., Algal Research - Biomass Biofuels and Bioproducts, 11, 148-155.
- Armitage, E.G.; Kotze, H.L.; Allwood, J.W.; Dunn, W.B.; Goodacre, R.; Williams, K.J. (2015) Metabolic profiling reveals potential metabolic markers associated with Hypoxia Inducible Factor-mediated signaling in hypoxic cancer cells., Scientific Reports, 5, Article No. 15649.
- Allwood, J.W.; Alrabiah, H.; Correa, E.; Vaughan, A. Xu, Y.; Upton, M.; Goodacre, R. (2015) A workflow for bacterial metabolic fingerprinting and lipid profiling: application to Ciprofloxacin challenged Escherichia coli., Metabolomics, 11, 438-453.
- Armitage, E.G.; Kotze, H.L.; Allwood, J.W.; Dunn, W.B.; Goodacre, R.; Williams, K.J. (2015) Metabolic profiling reveals potential metabolic markers associated with Hypoxia Inducible Factor-mediated signalling in hypoxic cancer cells., Scientific Reports, 5, Article 15649.
- Gehmlich, K.; Dodd, M.; Allwood, J.W.; Kelly, M.; Bellahcene, M.; Lad, H.; Stockenhuber, A.; Hooper, C.; Ashrafian, H.; Redwood, C.; Carrier, L.; Dunn, W.B. (2015) Changes in the cardiac metabolome caused by perhexiline treatment in a mouse model of hypertrophic cardiomyopathy., Molecular BioSystems, 2, 564-573.
- Mullard, G.; Allwood, J.W.; Weber, R.; Brown, M.; Begley, P.; Hollywood, K.A.; Jones, M.; Unwin, R.D.; Bishop, P.N.; Cooper, G.J.S.; Dunn, W.B. (2015) A new strategy for MS/MS data acquisition applying multiple data dependent experiments on Orbitrap mass spectrometers in non-targeted metabolomic applications., Metabolomics, 11, 1068-1080.
- Muhamadali, H.; Xu, Y.; Ellis, D.I.; Allwood, J.W.; Rattray, N.J.W.; Correa, E.; Alrabiah, H.; Lloyd, J.R.; Goodacre, R. (2015) Metabolic profiling of Geobacter sulfurreducens during industrial bioprocess scale-up., Applied and Environmental Microbiology, 81, 3288-3298.
- Allwood, J.W.; Chandra, S.; Xu, Y.; Dunn, W.B.; Correa, E.; Hopkins, L.; Goodacre, R.; Tobin, A.K.; Bowsher, C.G. (2015) Profiling of spatial metabolite distributions in wheat leaves under normal and nitrate limiting conditions., Phytochemistry, 115, 99-111.
- Dyson, B.C.; Allwood, J.W.; Feil, R.; Xu, Y.; Miller, M.; Bowsher, C.G.; Goodacre, R.; Lunn, J.E.; Johnson, G.N. (2015) Acclimation of metabolism to light in Arabidopsis thaliana: the glucose 6-phosphate/phosphate translocator GPT2 directs metabolic acclimation., Plant, Cell and Environment, 38, 1404-1417.
- Kim, D.-H.; Allwood, J.W.; Moore, R.E.; Marsden-Edwards, E.; Dunn, W.B.; Xu, Y.; Hampson, L.; Hampson, I.N.; Goodacre, R. (2014) A metabolomics investigation into the effects of HIV protease inhibitors on HPV16 E6 expressing cervical carcinoma cells., Molecular Biosystems, 10, 398-411.
- Alrabiah, H.; Xu, Y.; Rattray, N.J.W.; Vaughan, A.; Gibreel, T.; Sayqal, A.; Upton, M.; Allwood, J.W.; Goodacre, R. (2014) Multiple metabolomics of uropathogenic E. coli reveal different information content in terms of metabolic potential compared to virulence factors., Analyst, 139, 4193-4199.
- Allwood, J.W.; Cheung, W.; Xu, Y.; Mumm, R.; De Vos, R.C.H.; Deborde, C.; Biais, B.; Maucourt, M.; Berger, Y.; Schaffer, A.A.; Rolin, D.; Moing, A.; Hall, R.D.; Goodacre, R. (2014) Metabolomics in melon: a new opportunity for aroma analysis., Phytochemistry, 99, 61-72.
- Hooks, M.A.; Allwood, J.W.; Harrison, J.K.D.; Kopka, J.; Erban, A.; Goodacre, R.; Balk, J. (2014) Selective induction and subcellular distribution of ACONITASE 3 reveal the importance of cytosolic citrate metabolism during lipid mobilization in Arabidopsis., Biochemical Journal, 463, 309-317.
- Bradbury, J.; Genta-Jouve, G.; Allwood, J.W.; Dunn, W.B.; Goodacre, R.; Knowles, J.D.; He, S.; Viant, M.R. (2014) MUSCLE: automated multi-objective evolutionary optimisation of LC-MS/MS analysis., Bioinformatics, 31, 975-977.
- Allwood, J.W.; Winder, C.L.; Dunn, W.B.; Goodacre, R. (2013) Considerations in sample preparation, collection and extraction approaches applied in microbial, plant and mammalian metabolic profiling., In: Lutz, N.W., Sweedler, J. & Wevers, R.A. (eds.). Methodologies for Metabolomics: Experimental Strategies and Techniques. Cambridge University Press, Chapter 4, pp79-118.
- Mabbott, S.; Correa, E.; Cowcher, D.P.; Allwood, J.W.; Goodacre, R. (2013) Optimisation of parameters for the quantitative surface-enhanced Raman scattering detection of mephedrone using a fractional factorial design and a portable Raman spectrometer., Analytical Chemistry, 85, 923-931.
- Allwood, J.W.; Weber, R.J.M.; Zhou, J.; He, S.; Viant, M.R.; Dunn, W.B. (2013) CASMI - The small molecule identification process from a Birmingham perspective., Metabolites, 3, 397-411.
- Kotze, H.L.; Armitage, E.G.; Sharkey, K.J.; Allwood, J.W.; Dunn, W.B.; Williams, K.J.; Goodacre, R. (2013) A novel untargeted metabolomics correlation-based network analysis incorporating human metabolic reconstructions., BMC Systems Biology, 7, Article No. 107.
- Zhou, J.; Weber, R.J.M.; Allwood, J.W.; Mistrik, R.; Zhu, Z.; Ji, Z.; Chen, S.; Dunn, W.B.; He, S.; Viant, M.R. (2013) HAMMER: Automated operation of mass frontier to construct in-silico mass spectral fragmentation libraries., Bioinformatics, 30, 581-583.
- Allwood, J.W.; Heald, J.; Lloyd, A.J.; Goodacre, R.; Mur, L.A.J. (2012) Separating the inseparable: The metabolomic analysis of plant-pathogen interactions., In: Hardy, N. & Hall, R. (eds.) Plant Metabolomics. Methods in Molecular Biology (Methods and Protocols). Humana Press, Volume 860, pp31-49..
- Allwood, J.W.; Parker, D.; Beckmann, M.; Draper, J.; Goodacre, R. (2012) Fourier transform ion cyclotron resonance mass spectrometry for plant metabolite profiling and metabolite identification., In: Hardy, N. & Hall, R. (eds.) Plant Metabolomics. Methods in Molecular Biology (Methods and Protocols). Humana Press, Volume 860, pp157-176.
- Ellis, D.I.; Brewster, V.L.; Dunn, W.B.; Allwood, J.W.; Golovanov, A.P.; Goodacre, R. (2012) Fingerprinting food: current technologies for the detection of food adulteration and contamination., Chemical Society Reviews, 41, 5706-5727.
- Vaughan, A.A.; Dunn, W.B.; Allwood, J.W.; Wedge, D.C.; Blackhall, F.H.; Whetton, A.D.; Dive, C.; Goodacre, R. (2012) Liquid chromatography-mass spectrometry calibration transfer and metabolomics data fusion., Analytical Chemistry, 84, 9848-9857.
- Kopka, J.; Walther, D.; Allwood, J.W.; Goodacre, R. (2011) Progress in chemometrics and biostatistics for plant applications, or: a good red wine is a bad white wine., In: Hall, R.D. (ed.). Biology of Plant Metabolomics. Blackwell, Oxford UK, Chapter 10, pp317-342.
- Allwood, J.W.; De Vos, R.C.H.; Moing, A.; Deborde, C.; Erban, A.; Kopka, J.; Goodacre, R.; Hall, R.D. (2011) Plant metabolomics and its potential for systems biology research: background concepts, technology and methodology., In: Jameson, D., Verma, M. & Westerhoff, H.V. (eds.). Methods in Enzymology: Methods in Systems Biology. Elsevier Science, 500, 299-336.
- Moing, A.; Aharoni, A.; Biais, B.; Rogachev, I.; Meir, S.; Brodsky, L.; Allwood, J.W.; Erban, A.; Dunn, W.B.; Kay, L.; de Koning, S.; de Vos, C.H.R.; Jonker, H.; Mumm, R.; Deborde, C.; Maucourt, M.; Bernillon, S.; Gibon, Y.; Hansen, T.H.; Husted, S.; Goodacre, R.; Kopka, J.; Schjoerring, J.K.; Rolin, D.; Hall, R.D. (2011) Extensive metabolic cross-talk in melon fruit revealed by spatial and developmental combinatorial metabolomics., New Phytologist, 190, 683-696.
- Wedge, D.C.; Allwood, J.W.; Dunn, W.B.; Vaughan, A.A.; Simpson, K.; Brown, M.; Priest, L.; Blackhall, F.H.; Whetton, A.D.; Dive, C.; Goodacre, R. (2011) Is serum or plasma more appropriate for inter-subject comparisons in metabolomic studies? An assessment in patients with small-cell lung cancer., Analytical Chemistry, 83, 6689-6697.
- Lloyd, A.J.; Allwood, J.W.; Winder, C.L.; Dunn, W.B.; Heald, J.K.; Cristescu, S.M.; Sivakumaran, A.; Harren, J.F.M.; Mulema, J.; Denby, K.; Goodacre, R.; Smith, A.R.; Mur, L.A.J. (2011) Metabolomic approaches reveal that cell wall modifications play a major role in ethylene-mediated resistance against Botrytis cinerea., Plant Journal, 67, 852-868.
- Allwood, J.W.; Clarke, A.; Goodacre, R.; Mur, L.A.J. (2010) Dual metabolomics: A novel approach to understanding plant-pathogen interactions., Phytochemistry, 71, 590-597.
- Biais, B.; Beauvoit, B.; Allwood, J.W.; Deborde, C.; Maucort, M.; Goodacre, R.; Rolin, D.; Moing, A. (2010) Metabolic acclimation to hypoxia revealed by metabolite gradients in melon fruit., Journal of Plant Physiology, 167, 242-245.
- Allwood, J.W.; Goodacre, R. (2010) An introduction to Liquid Chromatography Mass Spectrometry (LC-MS) instrumentation applied in plant metabolomic analyses., Phytochemical Analysis, 21, 33-47.
- Kim, D.-H.; Jarvis, R.M.; Xu, Y.; Oliver, A.W.; Allwood, J.W.; Hampson, L.; Hampson, I.N.; Goodacre, R. (2010) Combining metabolic fingerprinting and footprinting to understand the phenotypic response of HPV16 E6 expressing cervical carcinoma cells exposed to the HIV anti-viral drug lopinavir., Analyst, 135, 1235-1244.
- Kim, D.-H.; Jarvis, R.M.; Allwood, J.W.; Batman, G.; Moore, R.E.; Marsden-Edwards, E.; Hampson, L.; Hampson, I.N.; Goodacre, R. (2010) Raman chemical mapping reveals site of action of HIV protease inhibitors in HPV16 E6 expressing cervical carcinoma cells., Analytical and Bioanalytical Chemistry, 398, 3051-3061.
- Lowe, R.G.T.; Allwood, J.W.; Galster, A.M.; Urban, M.; Daudi, A.; Canning, G.; Ward, J.L.; Beale, M.H.; Hammond-Kosack, K.E. (2010) A combined 1H nuclear magnetic resonance and electrospray ionization-mass spectrometry analysis to understand the basal metabolism of plant-pathogenic Fusarium spp., Molecular Plant-Microbe Interactions, 23, 1605-1618.
- Jansen, J.J.; Allwood, J.W.; Marsden-Edwards, E.; van der Putten, W.H.; Goodacre, R.; van Dam, N.M. (2009) Metabolomic analysis of the interaction between plants and herbivores., Metabolomics, 5, Article No. 150.
- Biais, B.; Allwood, J.W.; Deborde, C.; Xu, Y.; Maucourt, M.; Beauvoit, B.; Dunn, W.B.; Jacob, D.; Goodacre, R.; Rolin, D.; Moing, A. (2009) 1H-NMR, GC-EI-TOFMS, and dataset correlation for fruit metabolomics: application to spatial metabolite analysis in melon., Analytical Chemistry, 81, 2884-2894.
- Allwood, J.W.; Erban, A.; de Koning, S.; Dunn, W.B.; Luedemann, A.; Lommen, A.; Kay, L.; Löscher, R.; Kopka, J.; Goodacre, R. (2009) Inter-laboratory reproducibility of fast gas chromatography - electron impact - time of flight mass spectrometry (GC-EI-TOFMS) based plant metabolomics., Metabolomics, 5, 479-496.
- Allwood, J.W.; Ellis, D.I.; Goodacre, R. (2008) Metabolomic technologies and their application to the study of plants and plant-host interactions., Physiologia Plantarum, 132, 117-135.
- Ellis, D.I.; Dunn, W.B.; Griffin, J.L.; Allwood, J.W.; Goodacre, R. (2007) Metabolic fingerprinting as a diagnostic tool., Pharmacogenomics, 8, 1243 -1266.
- Allwood, J.W.; Ellis, D.I.; Heald, J.K.; Goodacre, R.; Mur, L.A.J. (2006) Metabolomic approaches reveal that phosphatidic and phosphatidyl glycerol phospholipids are major discriminatory non-polar metabolites in responses by Brachypodium distachyon to challenge by Magnaporthe grisea., Plant Journal, 46, 351-368.
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